Table 3 AUROCs comparison between ions of peptide m/z 520.3, APRI, FIB-4 and Forn’s index
1-Specificity S0-2 vs S3-4 | Sensitivity S0-2 vs S3-4 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | Std. deviation | Std. error mean | 95% CI of the difference | t | df | P-value | Mean | Std. deviation | Std. error mean | 95% CI of the difference | t | df | P-value | ||||
APRI | 520.3/176.1 | (0.01) | 0.48 | 0.05 | (0.12) | 0.10 | (0.16) | 76.00 | 0.87 | 0.09 | 0.60 | 0.07 | (0.04) | 0.23 | 1.34 | 76.00 | 0.19 |
520.3/353.7 | 0.18 | 0.46 | 0.06 | 0.06 | 0.29 | 3.07 | 63.00 | 0.00 | 0.18 | 0.56 | 0.07 | 0.04 | 0.32 | 2.62 | 63.00 | 0.01 | |
520.3/459.8 | 0.16 | 0.41 | 0.05 | 0.06 | 0.27 | 3.18 | 62.00 | 0.00 | 0.15 | 0.57 | 0.07 | 0.01 | 0.30 | 2.15 | 62.00 | 0.04 | |
520.3/503.3 | 0.08 | 0.43 | 0.05 | (0.03) | 0.19 | 1.54 | 60.00 | 0.13 | 0.18 | 0.57 | 0.07 | 0.04 | 0.33 | 2.53 | 60.00 | 0.01 | |
520.9/351.3 | (0.03) | 0.51 | 0.05 | (0.14) | 0.08 | (0.56) | 86.00 | 0.57 | 0.02 | 0.64 | 0.07 | (0.12) | 0.15 | 0.25 | 86.00 | 0.80 | |
520.9/593.1 | 0.07 | 0.48 | 0.06 | (0.04) | 0.18 | 1.30 | 76.00 | 0.20 | 0.06 | 0.59 | 0.07 | (0.08) | 0.19 | 0.86 | 76.00 | 0.39 | |
FIB-4 | 520.3/176.1 | (0.05) | 0.52 | 0.06 | (0.17) | 0.07 | (0.84) | 76.00 | 0.40 | 0.11 | 0.58 | 0.07 | (0.02) | 0.25 | 1.74 | 76.00 | 0.09 |
520.3/353.7 | 0.15 | 0.49 | 0.06 | 0.03 | 0.27 | 2.42 | 63.00 | 0.02 | 0.20 | 0.54 | 0.07 | 0.06 | 0.33 | 2.95 | 63.00 | 0.00 | |
520.3/459.8 | 0.14 | 0.44 | 0.06 | 0.03 | 0.25 | 2.49 | 62.00 | 0.02 | 0.17 | 0.55 | 0.07 | 0.03 | 0.31 | 2.44 | 62.00 | 0.02 | |
520.3/503.3 | 0.06 | 0.45 | 0.06 | (0.05) | 0.18 | 1.08 | 60.00 | 0.29 | 0.20 | 0.55 | 0.07 | 0.05 | 0.34 | 2.77 | 60.00 | 0.01 | |
520.9/351.3 | (0.07) | 0.53 | 0.06 | (0.18) | 0.04 | (1.22) | 86.00 | 0.23 | 0.04 | 0.62 | 0.07 | (0.09) | 0.17 | 0.59 | 86.00 | 0.56 | |
520.9/593.1 | 0.03 | 0.53 | 0.06 | (0.09) | 0.15 | 0.51 | 76.00 | 0.61 | 0.08 | 0.57 | 0.07 | (0.05) | 0.21 | 1.24 | 76.00 | 0.22 | |
Forn’s | 520.3/176.1 | (0.08) | 0.49 | 0.06 | (0.19) | 0.03 | (1.42) | 76.00 | 0.16 | 0.13 | 0.60 | 0.07 | (0.00) | 0.27 | 1.93 | 76.00 | 0.06 |
520.3/353.7 | 0.11 | 0.47 | 0.06 | (0.01) | 0.22 | 1.83 | 63.00 | 0.04 | 0.22 | 0.55 | 0.07 | 0.08 | 0.36 | 3.21 | 63.00 | 0.00 | |
520.3/459.8 | 0.10 | 0.42 | 0.05 | (0.01) | 0.20 | 1.82 | 62.00 | 0.04 | 0.19 | 0.56 | 0.07 | 0.05 | 0.33 | 2.72 | 62.00 | 0.01 | |
520.3/503.3 | 0.02 | 0.43 | 0.06 | (0.09) | 0.13 | 0.32 | 60.00 | 0.75 | 0.22 | 0.57 | 0.07 | 0.08 | 0.37 | 3.06 | 60.00 | 0.00 | |
520.9/351.3 | (0.10) | 0.51 | 0.05 | (0.20) | 0.01 | (1.77) | 86.00 | 0.08 | 0.05 | 0.64 | 0.07 | (0.08) | 0.19 | 0.79 | 86.00 | 0.43 | |
520.9/593.1 | 0.00 | 0.50 | 0.06 | (0.11) | 0.11 | 0.03 | 76.00 | 0.98 | 0.10 | 0.59 | 0.07 | (0.04) | 0.23 | 1.45 | 76.00 | 0.15 | |
1-Specificity S0-1 vs S2-4 | Sensitivity S0-1 vs S2-4 | ||||||||||||||||
Mean | Std. deviation | Std. error mean | 95% CI of the difference | t | df | P-value | Mean | Std. deviation | Std. error mean | 95% CI of the difference | t | df | P-value | ||||
APRI | 520.3/176.1 | 0.02 | 0.55 | 0.06 | (0.11) | 0.14 | 0.24 | 76.00 | 0.81 | 0.11 | 0.56 | 0.06 | (0.01) | 0.24 | 1.79 | 76.00 | 0.08 |
520.3/353.7 | 0.16 | 0.52 | 0.06 | 0.03 | 0.29 | 2.50 | 63.00 | 0.02 | 0.21 | 0.53 | 0.07 | 0.07 | 0.34 | 3.12 | 63.00 | 0.00 | |
520.3/459.8 | 0.20 | 0.48 | 0.06 | 0.08 | 0.32 | 3.31 | 62.00 | 0.00 | 0.10 | 0.56 | 0.07 | (0.04) | 0.24 | 1.40 | 62.00 | 0.17 | |
520.3/503.3 | 0.12 | 0.47 | 0.06 | 0.00 | 0.25 | 2.05 | 60.00 | 0.04 | 0.18 | 0.58 | 0.07 | 0.03 | 0.33 | 2.47 | 60.00 | 0.02 | |
520.9/351.3 | (0.03) | 0.58 | 0.06 | (0.15) | 0.09 | (0.51) | 86.00 | 0.61 | 0.05 | 0.61 | 0.07 | (0.08) | 0.18 | 0.70 | 86.00 | 0.49 | |
520.9/593.1 | 0.03 | 0.55 | 0.06 | (0.10) | 0.15 | 0.42 | 76.00 | 0.68 | 0.12 | 0.56 | 0.06 | (0.01) | 0.24 | 1.82 | 76.00 | 0.07 | |
FIB-4 | 520.3/176.1 | 0.02 | 0.56 | 0.06 | (0.10) | 0.15 | 0.36 | 76.00 | 0.72 | 0.10 | 0.54 | 0.06 | (0.02) | 0.23 | 1.66 | 76.00 | 0.10 |
520.3/353.7 | 0.18 | 0.51 | 0.06 | 0.05 | 0.31 | 2.75 | 63.00 | 0.01 | 0.18 | 0.52 | 0.07 | 0.05 | 0.31 | 2.80 | 63.00 | 0.01 | |
520.3/459.8 | 0.22 | 0.48 | 0.06 | 0.10 | 0.34 | 3.59 | 62.00 | 0.00 | 0.07 | 0.56 | 0.07 | (0.07) | 0.21 | 1.05 | 62.00 | 0.30 | |
520.3/503.3 | 0.14 | 0.47 | 0.06 | 0.02 | 0.26 | 2.40 | 60.00 | 0.02 | 0.16 | 0.58 | 0.07 | 0.01 | 0.30 | 2.08 | 60.00 | 0.04 | |
520.9/351.3 | (0.02) | 0.59 | 0.06 | (0.15) | 0.10 | (0.38) | 86.00 | 0.70 | 0.04 | 0.59 | 0.06 | (0.09) | 0.16 | 0.55 | 86.00 | 0.58 | |
520.9/593.1 | 0.03 | 0.57 | 0.06 | (0.09) | 0.16 | 0.53 | 76.00 | 0.60 | 0.10 | 0.54 | 0.06 | (0.02) | 0.23 | 1.69 | 76.00 | 0.10 | |
Forn’s | 520.3/176.1 | (0.03) | 0.56 | 0.06 | (0.16) | 0.09 | (0.53) | 76.00 | 0.60 | 0.19 | 0.56 | 0.06 | 0.06 | 0.31 | 2.93 | 76.00 | 0.00 |
520.3/353.7 | 0.11 | 0.53 | 0.07 | (0.02) | 0.24 | 1.67 | 63.00 | 0.10 | 0.28 | 0.51 | 0.06 | 0.15 | 0.41 | 4.40 | 63.00 | 0.00 | |
520.3/459.8 | 0.15 | 0.49 | 0.06 | 0.02 | 0.27 | 2.40 | 62.00 | 0.02 | 0.17 | 0.54 | 0.07 | 0.04 | 0.31 | 2.53 | 62.00 | 0.01 | |
520.3/503.3 | 0.07 | 0.48 | 0.06 | (0.05) | 0.20 | 1.21 | 60.00 | 0.23 | 0.25 | 0.56 | 0.07 | 0.11 | 0.40 | 3.55 | 60.00 | 0.00 | |
520.9/351.3 | (0.07) | 0.57 | 0.06 | (0.20) | 0.05 | (1.22) | 86.00 | 0.23 | 0.11 | 0.62 | 0.07 | (0.02) | 0.24 | 1.64 | 86.00 | 0.11 | |
520.9/593.1 | (0.02) | 0.56 | 0.06 | (0.15) | 0.10 | (0.35) | 76.00 | 0.72 | 0.19 | 0.56 | 0.06 | 0.06 | 0.31 | 2.96 | 76.00 | 0.00 | |