Figure 4

AUROCs of ion pairs generated from peptide m/z 520.3. Six models established by ions of peptide m/z 520.3 (176.1, 353.7, 459.8, 503.3, 351.3 and 593.1) and three serological models currently in clinical use (APRI, FIB-4, Forn’s Index) were evaluated for their diagnostic potential by AUROC. A-1: AUROCs of APRI, FIB-4, Forn’s Indices are 0.724 ~ 0.876 (S2-4 versus S0-1). A-2: AUROCs of APRI, FIB-4, Forn’s Indices are 0.758 ~ 0.839 (S3-4 versus S0-2). B-1: AUROCs of 6 ions from 520.3 models are 0.724 ~ 0.940 (S2-4 versus S0-1). B-2: AUROCs of 6 ions from 520.3 models are 0.883 ~ 0.937 (S3-4 versus S0-2). C-1: AUROCs of 4 ions from 520.3 models are 0.694 ~ 0.856 (G2-4 versus G0-1). C-2: AUROCs of 4 ions from 520.3 models are 0.731 ~ 0.888 (G3-4 versus G0-2).