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Table 4 Pharmacokinetic parameters of CDDP (5 mg/kg, i.v.) in rats bile after head and neck irradiation with and without 0.5 and 2 Gy

From: Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

Parameters Controls One phase of head and neck irradiation
0 Gy 0.5 Gy 2 Gy
AUC (min μg/mL) 262 ± 52 542 ± 192* 611 ± 66*
t1/2 (min) 32 ± 15 27 ± 5.1 28 ± 7.8
Cmax (μg/mL) 12 ± 1.0 19 ± 10 18 ± 2.8
MRT (min) 28 ± 9.4 33 ± 8.3 32 ± 11.6
CL (mL/kg/min) 19 ± 3.4 10 ± 2.9* 8.2 ± 0.9*
Vss (mL/kg) 544 ± 202 337 ± 150 257 ± 94
  1. AUC area under the plasma concentration, vs. time curve, t 1/2  terminal elimination phase half-life, Cmax maximum observed plasma concentration MRT mean residence time, CL total plasma clearance, Vss volume of distribution at steady state.
  2. *The mean difference is significant at the 0.05 level in comparison to the control group.