Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

Table 4 Pharmacokinetic parameters of CDDP (5 mg/kg, i.v.) in rats bile after head and neck irradiation with and without 0.5 and 2 Gy

Parameters	Controls	One phase of head and neck irradiation
Parameters	0 Gy	0.5 Gy	2 Gy
AUC (min μg/mL)	262 ± 52	542 ± 192*	611 ± 66*
t_1/2 (min)	32 ± 15	27 ± 5.1	28 ± 7.8
Cmax (μg/mL)	12 ± 1.0	19 ± 10	18 ± 2.8
MRT (min)	28 ± 9.4	33 ± 8.3	32 ± 11.6
CL (mL/kg/min)	19 ± 3.4	10 ± 2.9*	8.2 ± 0.9*
Vss (mL/kg)	544 ± 202	337 ± 150	257 ± 94

AUC area under the plasma concentration, vs. time curve, t_1/2 terminal elimination phase half-life, Cmax maximum observed plasma concentration MRT mean residence time, CL total plasma clearance, Vss volume of distribution at steady state.
*The mean difference is significant at the 0.05 level in comparison to the control group.

ISSN: 1479-5876