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Table 3 Pharmacokinetic parameters of CDDP (5 mg/kg, i.v.) in rats plasma after with or without head & neck irradiation at control, 0.5 and 2 Gy

From: Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

Parameters Controls One phase of head and neck irradiation
0 Gy 0.5 Gy 2 Gy
AUC (min μg/mL) 722 ± 164 484 ± 52* 511 ± 138*
t1/2 (min) 269 ± 108 215 ± 88.5 172 ± 44.6
Cmax (μg/mL) 15.0 ± 2.2 9.6 ± 0.7* 10.1 ± 1.3*
MRT (min) 291 ± 131 248 ± 97.5 249 ± 116
CL (mL/kg/min) 4 ± 1.2 6.8 ± 1.1* 6 ± 0.9*
Vss (mL/kg) 1233 ± 470 1621 ± 520 1626 ± 683
  1. AUC area under the plasma concentration, vs. time curve, t 1/2  terminal elimination phase half-life, Cmax maximum observed plasma concentration, MRT mean residence time, CL total plasma clearance, Vss volume of distribution at steady state.
  2. *The mean difference is significant at the 0.05 level in comparison to the control group.