From: Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin
Parameters | Controls | One phase of head and neck irradiation | |
---|---|---|---|
0Â Gy | 0.5Â Gy | 2Â Gy | |
AUC (min μg/mL) | 722 ± 164 | 484 ± 52* | 511 ± 138* |
t1/2 (min) | 269 ± 108 | 215 ± 88.5 | 172 ± 44.6 |
Cmax (μg/mL) | 15.0 ± 2.2 | 9.6 ± 0.7* | 10.1 ± 1.3* |
MRT (min) | 291 ± 131 | 248 ± 97.5 | 249 ± 116 |
CL (mL/kg/min) | 4 ± 1.2 | 6.8 ± 1.1* | 6 ± 0.9* |
Vss (mL/kg) | 1233 ± 470 | 1621 ± 520 | 1626 ± 683 |