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Table 3 Pharmacokinetic parameters of CDDP (5 mg/kg, i.v.) in rats plasma after with or without head & neck irradiation at control, 0.5 and 2 Gy

From: Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

Parameters

Controls

One phase of head and neck irradiation

0 Gy

0.5 Gy

2 Gy

AUC (min μg/mL)

722 ± 164

484 ± 52*

511 ± 138*

t1/2 (min)

269 ± 108

215 ± 88.5

172 ± 44.6

Cmax (μg/mL)

15.0 ± 2.2

9.6 ± 0.7*

10.1 ± 1.3*

MRT (min)

291 ± 131

248 ± 97.5

249 ± 116

CL (mL/kg/min)

4 ± 1.2

6.8 ± 1.1*

6 ± 0.9*

Vss (mL/kg)

1233 ± 470

1621 ± 520

1626 ± 683

  1. AUC area under the plasma concentration, vs. time curve, t 1/2  terminal elimination phase half-life, Cmax maximum observed plasma concentration, MRT mean residence time, CL total plasma clearance, Vss volume of distribution at steady state.
  2. *The mean difference is significant at the 0.05 level in comparison to the control group.