Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

Table 2 Pharmacokinetic parameters of 5-Fluorouracil (100 mg/kg, i.v.) in rats bile after head and neck irradiation with and without 0.5 and 2 Gy

Parameters	Controls	One phase of head and neck irradiation
Parameters	0 Gy	0.5 Gy	2 Gy
AUC (min μg/mL)	1218 ± 22	1366 ± 86^*	1522 ± 111^*
t_1/2 (min)	9.4 ± 0.5	9.2 ± 0.2	13.3 ± 1.1^*
Cmax (μg/mL)	129 ± 22	104 ± 14^*	88 ± 17^*
MRT (min)	10.0 ± 1.0	10.7 ± 0.5	14.5 ± 0.6^*
CL (mL/kg/min)	80.3 ± 2.3	76.3 ± 5.4	65.6 ± 4.5^*
Vss (mL/kg)	812 ± 96	820 ± 66	952 ± 69

AUC area under the plasma concentration, vs. time curve, t_1/2 terminal elimination phase half-life, Cmax maximum observed plasma concentration, MRT mean residence time, CL total plasma clearance, Vss volume of distribution at steady state.
*The mean difference is significant at the 0.05 level in comparison to the control group.

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