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Table 2 Pharmacokinetic parameters of 5-Fluorouracil (100 mg/kg, i.v.) in rats bile after head and neck irradiation with and without 0.5 and 2 Gy

From: Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

Parameters Controls One phase of head and neck irradiation
0 Gy 0.5 Gy 2 Gy
AUC (min μg/mL) 1218 ± 22 1366 ± 86* 1522 ± 111*
t1/2 (min) 9.4 ± 0.5 9.2 ± 0.2 13.3 ± 1.1*
Cmax (μg/mL) 129 ± 22 104 ± 14* 88 ± 17*
MRT (min) 10.0 ± 1.0 10.7 ± 0.5 14.5 ± 0.6*
CL (mL/kg/min) 80.3 ± 2.3 76.3 ± 5.4 65.6 ± 4.5*
Vss (mL/kg) 812 ± 96 820 ± 66 952 ± 69
  1. AUC area under the plasma concentration, vs. time curve, t 1/2  terminal elimination phase half-life, Cmax maximum observed plasma concentration, MRT mean residence time, CL total plasma clearance, Vss volume of distribution at steady state.
  2. *The mean difference is significant at the 0.05 level in comparison to the control group.