Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

Table 1 Pharmacokinetic parameters of 5-Fluorouracil (100 mg/kg, i.v.) in rats plasma after head and neck irradiation with and without 0.5 and 2 Gy

Parameters	Controls	One phase of head and neck irradiation
Parameters	0 Gy	0.5 Gy	2 Gy
AUC (min μg/mL)	4748 ± 360	4017 ± 358*	3993 ± 191*
t_1/2 (min)	33.1 ± 11.5	35.5 ± 9.7	39.0 ± 5.6
Cmax (μg/mL)	165 ± 35	165 ± 17	167 ± 39
MRT (min)	37.0 ± 2.8	30 ± 4.5*	29 ± 2.9*
CL (mL/kg/min)	21.2 ± 1.7	25 ± 4.8	27 ± 5.7*
Vss (mL/kg)	785 ± 96	784 ± 88	815 ± 130

AUC area under the plasma concentration, vs. time curve, t_1/2 terminal elimination phase half-life, Cmax maximum observed plasma concentration, MRT mean residence time, CL total plasma clearance, Vss volume of distribution at steady state.
*The mean difference is significant at the 0.05 level in comparison to the control group.

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