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Table 1 Pharmacokinetic parameters of 5-Fluorouracil (100 mg/kg, i.v.) in rats plasma after head and neck irradiation with and without 0.5 and 2 Gy

From: Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

Parameters Controls One phase of head and neck irradiation
0 Gy 0.5 Gy 2 Gy
AUC (min μg/mL) 4748 ± 360 4017 ± 358* 3993 ± 191*
t1/2 (min) 33.1 ± 11.5 35.5 ± 9.7 39.0 ± 5.6
Cmax (μg/mL) 165 ± 35 165 ± 17 167 ± 39
MRT (min) 37.0 ± 2.8 30 ± 4.5* 29 ± 2.9*
CL (mL/kg/min) 21.2 ± 1.7 25 ± 4.8 27 ± 5.7*
Vss (mL/kg) 785 ± 96 784 ± 88 815 ± 130
  1. AUC area under the plasma concentration, vs. time curve, t 1/2  terminal elimination phase half-life, Cmax maximum observed plasma concentration, MRT mean residence time, CL total plasma clearance, Vss volume of distribution at steady state.
  2. *The mean difference is significant at the 0.05 level in comparison to the control group.