Oxidative damage and myofiber degeneration in the gastrocnemius of patients with peripheral arterial disease

Table 3 Association of myofiber cross-sectional area and oxidative damage, for PAD and control patients

	Q1	Q2	Q3	Q4
PAD myofiber area by carbonyl (μ ² )	3,965 ± 1778^‡	3,931 ± 1,6320	3,788 ± 1,539	3,376 ± 1,422*
Control myofiber area by carbonyl (μ ² )	5,074 ± 1,696	5,382 ± 1,521	5,396 ± 1,568	5,442 ± 1,387
PAD myofiber area by HNE (μ ² )	3,945 ± 1,329	3,921 ± 1,486	3,832 ± 1,621	3,320 ± 1,568*
Control myofiber area by HNE (μ ² )	5,243 ± 1,402	5,389 ± 1,260	5,304 ± 999	5,364 ± 925

^‡Cross-sectional area in square microns (μ²) is presented as mean ± SD.
*Q4 is significantly different from Q1, Q2 and Q3 at p < 0.01 (for carbonyl groups and HNE adducts).
Myofibers were distributed on the basis of quartiles of carbonyl or HNE content into the following groups:
Q1: All fibers at or below the lower quartile.
Q2: All fibers at or below the median and above the lower quartileQ3: All fibers at or below the upper quartile and above the median.
Q4: All fibers above the upper quartile.

ISSN: 1479-5876