Table 2 The mRNA expression of PPAR and fibrosis-related genes in the ACE2-deficient hearts (n = 3)
Gene name | Description | Folds up- or down-regulation (Vs. WT mice) | P value |
|---|---|---|---|
PPARα | peroxisome proliferator activated receptor-α | −4.16 | 0.028 |
PPARδ | peroxisome proliferator activated receptor-δ | 1.02 | 0.968 |
PPARγ | peroxisome proliferator activated receptor-γ | −2.06 | 0.004 |
CTGF | connective tissue growth factor | 4.17 | 0.010 |
Col3A1 | collagen, type III, alpha 1 | 2.37 | 0.021 |
FN1 | fibronectin | 1.18 | 0.635 |
TGF-β1 | transforming growth factor-β1 | 2.62 | 0.001 |
TGF-β2 | transforming growth factor-β2 | 1.21 | 0.542 |