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Table 2 The mRNA expression of PPAR and fibrosis-related genes in the ACE2-deficient hearts (n = 3)

From: Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice

Gene name Description Folds up- or down-regulation (Vs. WT mice) P value
PPARα peroxisome proliferator activated receptor-α −4.16 0.028
PPARδ peroxisome proliferator activated receptor-δ 1.02 0.968
PPARγ peroxisome proliferator activated receptor-γ −2.06 0.004
CTGF connective tissue growth factor 4.17 0.010
Col3A1 collagen, type III, alpha 1 2.37 0.021
FN1 fibronectin 1.18 0.635
TGF-β1 transforming growth factor-β1 2.62 0.001
TGF-β2 transforming growth factor-β2 1.21 0.542