Genetic variance in Nitric Oxide Synthase and Endothelin Genes among children with and without Endothelial Dysfunction

Table 2 Distributions of allele and genotype frequencies of NOS1 SNPs in children with and without endothelial dysfunction

SNP	Allele	Endothelial function		Endothelial dysfunction		P- value	OR	CI 95%
SNP	Allele	n = 84		n = 38		P- value	OR	CI 95%
rs6490121	A/G	n	%	n	%
	AA	31	37	20	53	0.046	5.26	1.16-23.89
	GA	34	40	16	42
	GG	19	23	2	5
	Allele A	96	57	56	74
	Allele G	72	43	20	26
rs2293052	C/T	n	%	n	%
	CC	53	63	16	42	0.016	1.76	0.46-6.71
	TC	20	24	19	50
	TT	11	13	3	8
	Allele C	126	75	51	67
	Allele T	42	25	25	33
rs3825102	A/C	n	%	n	%
	AA	11	13	2	5	0.001	2.97	1.33-6.62
	AC	22	26	23	61
	CC	51	61	13	34
	Allele A	44	26	27	36
	Allele C	124	74	49	64
rs4767529	C/G	n	%	n	%
	CC	44	52	12	32	0.049	1.28	0.38-4.31
	GC	29	35	22	58
	GG	11	13	4	10
	Allele C	117	70	46	61
	Allele G	51	30	30	39
rs561712	A/G	n	%	n	%
	AA	13	15	4	10	0.037	2.34	1.03-5.32
	AG	30	36	23	61
	GG	41	49	11	29
	Allele A	56	33	31	41
	Allele G	112	67	45	59
rs549098	C/T	n	%	n	%
	CC	43	51	11	29	0.032	1.21	0.40-3.67
	TC	28	33	22	58
	TT	13	16	5	13
	Allele C	114	68	44	58
	Allele T	54	32	32	42
rs567581	A/G	n	%	n	%
	AA	13	16	5	13	0.022	2.70	1.19-6.14
	AG	27	32	22	58
	GG	44	52	11	29
	Allele A	53	32	32	42
	Allele G	115	68	44	58
rs483589	A/G	n	%	n	%
	AA	11	13	11	29	0.008	3.58	1.47-8.70
	AG	32	38	19	50
	GG	41	49	8	21
	Allele A	54	32	41	54
	Allele G	114	68	35	46
rs693534	A/G	n	%	n	%
	AA	11	13	13	34	0.011	2.67	1.15-6.18
	AG	32	38	15	40
	GG	41	49	10	26
	Allele A	54	32	41	54
	Allele G	114	68	35	46
rs9658255	C/G	n	%	n	%
	CC	41	49	10	26	0.029	0.37	0.14-0.95
	GC	32	38	17	45
	GG	11	13	11	29
	Allele C	114	68	37	49
	Allele G	54	32	39	51
rs1879417	C/T	n	%	n	%
	CC	14	17	14	37	0.02	2.73	1.07-6.91
	CT	38	45	17	45
	TT	32	38	7	18
	Allele C	66	39	45	59
	Allele T	102	61	31	41

ISSN: 1479-5876