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Table 3 Distribution of TLR2, TLR4, TLR6 and TLR9 gene polymorphisms in patients with TB and controls

From: Variants in toll-like receptor 9 gene influence susceptibility to tuberculosis in a Mexican population

    TB patients Controls  
(N=90) (N=90)
  SNP Genotype n F n F Pcorr
Allele
TLR2 rs3804099 T/T 59 (0.656) 48 (0.533) ns
C/T 26 (0.289) 36 (0.400) ns
C/C 5 (0.056) 6 (0.067) ns
T 144 (0.800) 132 (0.733) ns
C 36 (0.200) 48 (0.267) ns
rs7656411 T/T 58 (0.644) 53 (0.589) ns
G/T 29 (0.322) 33 (0.367) ns
G/G 3 (0.033) 4 (0.044) ns
T 145 (0.806) 139 (0.772) ns
G 35 (0.194) 41 (0.228) ns
rs121917864 C/C - - - -  
C/T 90 (1.0) 90 (1.0) ns
T/T - - - -  
C 90 (0.500) 90 (0.500) ns
T 90 (0.500) 90 (0.500) ns
rs5743708 G/G 90 (1.0) 90 (1.0) ns
G/A - - - -  
A/A - - - -  
G 180 (1.0) 180 (1.0) ns
A - - - -  
TLR4 rs5030710 T/T 87 (0.967) 87 (0.967) ns
C/T 3 (0.033) 3 (0.033) ns
C/C - - - -  
T 177 (0.983) 177 (0.983) ns
C 3 (0.017) 3 (0.017) ns
rs5030725 T/T 86 (0.978) 89 (0.989) ns
T/G 2 (0.022) 1 (0.011) ns
G/G - - - -  
T 178 (0.989) 179 (0.994) ns
G 2 (0.011) 1 (0.006) ns
rs12344353 T/T 89 (0.989) 90 (1.0) ns
C/T 1 (0.011) - - ns
C/C - - - -  
T 179 (0.994) 180 (1.0) ns
C 1 (0.006) - - ns
rs4986790 A/A 88 (0.978) 89 (0.989) ns
A/G 2 (0.022) 1 (0.011) ns
G/G - - - -  
A 178 (0.989) 179 (0.994) ns
G 2 (0.011) 1 (0.006) ns
TLR6 rs6815827 C/C 88 (0.978) 88 (0.989) ns
C/T 2 (0.022) 1 (0.011) ns
T/T - - - -  
C 178 (0.989) 177 (0.994) ns
T 2 (0.011) 1 (0.006) ns
TLR9 rs352139 G/G 19 (0.211) 35 (0.389) 0.01 *
A/G 48 (0.533) 41 (0.456) ns
A/A 23 (0.256) 14 (0.156) ns
G 86 (0.478) 111 (0.617) 0.01 **
A 94 (0.522) 69 (0.383) 0.01 ***
rs5743842 T/T - - - -  
T/C 2 (0.022) - - ns
C/C 88 (0.978) 90 (1.0) ns
T 2 (0.011) - - ns
C 178 (0.989) 180 (1.0) ns
rs5743836 T/T 82 (0.911) 78 (0.867) ns
T/C 8 (0.089) 12 (0.133) ns
C/C - - - -  
T 172 (0.956) 168 (0.933) ns
C 8 (0.044) 12 (0.067) ns
  1. * OR = 0.42, 95% CI = 0.21-0.81.
  2. ** OR = 0.56, 95% CI = 0.38-0.86.
  3. *** OR = 1.75, 95% CI = 1.15-2.67.
  4. ns: non significant; F: frequency; Pcorr: p values were corrected by Bonferroni. Statistically significant values are shown in bold.