Table 3 Distribution of TLR2, TLR4, TLR6 and TLR9 gene polymorphisms in patients with TB and controls
TB patients | Controls | ||||||
|---|---|---|---|---|---|---|---|
(N=90) | (N=90) | ||||||
SNP | Genotype | n | F | n | F | Pcorr | |
Allele | |||||||
TLR2 | rs3804099 | T/T | 59 | (0.656) | 48 | (0.533) | ns |
C/T | 26 | (0.289) | 36 | (0.400) | ns | ||
C/C | 5 | (0.056) | 6 | (0.067) | ns | ||
T | 144 | (0.800) | 132 | (0.733) | ns | ||
C | 36 | (0.200) | 48 | (0.267) | ns | ||
rs7656411 | T/T | 58 | (0.644) | 53 | (0.589) | ns | |
G/T | 29 | (0.322) | 33 | (0.367) | ns | ||
G/G | 3 | (0.033) | 4 | (0.044) | ns | ||
T | 145 | (0.806) | 139 | (0.772) | ns | ||
G | 35 | (0.194) | 41 | (0.228) | ns | ||
rs121917864 | C/C | - | - | - | - | ||
C/T | 90 | (1.0) | 90 | (1.0) | ns | ||
T/T | - | - | - | - | |||
C | 90 | (0.500) | 90 | (0.500) | ns | ||
T | 90 | (0.500) | 90 | (0.500) | ns | ||
rs5743708 | G/G | 90 | (1.0) | 90 | (1.0) | ns | |
G/A | - | - | - | - | |||
A/A | - | - | - | - | |||
G | 180 | (1.0) | 180 | (1.0) | ns | ||
A | - | - | - | - | |||
TLR4 | rs5030710 | T/T | 87 | (0.967) | 87 | (0.967) | ns |
C/T | 3 | (0.033) | 3 | (0.033) | ns | ||
C/C | - | - | - | - | |||
T | 177 | (0.983) | 177 | (0.983) | ns | ||
C | 3 | (0.017) | 3 | (0.017) | ns | ||
rs5030725 | T/T | 86 | (0.978) | 89 | (0.989) | ns | |
T/G | 2 | (0.022) | 1 | (0.011) | ns | ||
G/G | - | - | - | - | |||
T | 178 | (0.989) | 179 | (0.994) | ns | ||
G | 2 | (0.011) | 1 | (0.006) | ns | ||
rs12344353 | T/T | 89 | (0.989) | 90 | (1.0) | ns | |
C/T | 1 | (0.011) | - | - | ns | ||
C/C | - | - | - | - | |||
T | 179 | (0.994) | 180 | (1.0) | ns | ||
C | 1 | (0.006) | - | - | ns | ||
rs4986790 | A/A | 88 | (0.978) | 89 | (0.989) | ns | |
A/G | 2 | (0.022) | 1 | (0.011) | ns | ||
G/G | - | - | - | - | |||
A | 178 | (0.989) | 179 | (0.994) | ns | ||
G | 2 | (0.011) | 1 | (0.006) | ns | ||
TLR6 | rs6815827 | C/C | 88 | (0.978) | 88 | (0.989) | ns |
C/T | 2 | (0.022) | 1 | (0.011) | ns | ||
T/T | - | - | - | - | |||
C | 178 | (0.989) | 177 | (0.994) | ns | ||
T | 2 | (0.011) | 1 | (0.006) | ns | ||
TLR9 | rs352139 | G/G | 19 | (0.211) | 35 | (0.389) | 0.01 * |
A/G | 48 | (0.533) | 41 | (0.456) | ns | ||
A/A | 23 | (0.256) | 14 | (0.156) | ns | ||
G | 86 | (0.478) | 111 | (0.617) | 0.01 ** | ||
A | 94 | (0.522) | 69 | (0.383) | 0.01 *** | ||
rs5743842 | T/T | - | - | - | - | ||
T/C | 2 | (0.022) | - | - | ns | ||
C/C | 88 | (0.978) | 90 | (1.0) | ns | ||
T | 2 | (0.011) | - | - | ns | ||
C | 178 | (0.989) | 180 | (1.0) | ns | ||
rs5743836 | T/T | 82 | (0.911) | 78 | (0.867) | ns | |
T/C | 8 | (0.089) | 12 | (0.133) | ns | ||
C/C | - | - | - | - | |||
T | 172 | (0.956) | 168 | (0.933) | ns | ||
C | 8 | (0.044) | 12 | (0.067) | ns | ||