Table 2 Summary of the results of cytomorphological classification of CNHCs detected by ScreenCell® filtration in 8 ml of venous blood of patients with benign (n = 10), malignant (n = 30) renal tumors and healthy controls (n = 20)
| Â | Â | Â | Â | Â | Number of CNHC / 8Â ml | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Clinical data | Time point A* | Time point B** | Time point C*** | Time point D**** | ||||||||||
Patient number | Histological diagnosis | TNM | Grade | Venous invasion | MF | UMF | BF | MF | UMF | BF | MF | UMF | BF | MF | UMF | BF |
26 | angiomyolipoma | - | - | no | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
33 | angiomyolipoma | - | - | no | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
29 | benign cyst | - | - | - | 0 | 0 | 0 | 0 | 10 | 0 | 0 | 0 | 30 | 2 | 0 | 0 |
18 | cyst. nephroma | - | - | - | 51 | 4 | 0 | 2 | 0 | 0 | 0 | 127 | 30 | 30 | 380 | 0 |
3 | oncocytoma | - | - | no | 0 | 560 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 251 | 195 |
4 | oncocytoma | - | - | no | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 40 | 8 | 0 | 2 | 3 |
6 | oncocytoma | - | - | no | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 35 | 35 | 0 | 19 | 11 |
14 | oncocytoma | - | - | no | 0 | 0 | 0 | 0 | 39 | 0 | 37 | 8 | 0 | 21 | 5 | 0 |
17 | oncocytoma | - | - | no | 2 | 136 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 35 |
38 | oncocytoma | - | - | no | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
1 | ccRCC | T2aN0M0 | 2 | yes | 0 | 0 | 0 | 0 | 0 | 0 | ND | ND | ND | ND | ND | ND |
2 | ccRCC | T3aN0M0 | 2 | yes | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 10 | 0 | 0 | 0 | 0 |
7 | ccRCC | T2aN0M0 | 2 | no | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | ND | ND | ND |
9 | ccRCC | T1bN0M0 | 2 | no | 3 | 19 | 5 | 0 | 0 | 0 | ND | ND | ND | 0 | 0 | 0 |
10 | ccRCC | T1N0M0 | 2 | no | 16 | 0 | 10 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 22 | 16 |
11 | ccRCC | T1N0M0 | 2 | no | 0 | 0 | 0 | 2 | 0 | 0 | ND | ND | ND | 0 | 0 | 0 |
13 | ccRCC | T3aN0M0 | 3 | yes | 0 | 19 | 0 | 0 | 0 | 0 | 22 | 158 | 30 | ND | ND | ND |
15 | ccRCC | T1aN0M0 | 2 | no | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
16 | ccRCC | T1aN0M0 | 2 | no | 62 | 56 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
19 | ccRCC | T1aN0M0 | 1 | no | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 5 |
20 | ccRCC | T3aN0M0 | 3 | yes | 13 | 5 | 0 | 0 | 0 | 0 | 20 | 319 | 58 | ND | ND | ND |
22 | ccRCC | T1aN0M0 | 1 | no | 0 | 32 | 0 | 1 | 0 | 0 | 11 | 0 | 0 | ND | ND | ND |
23 | ccRCC | T1aN0M0 | 1 | no | 1 | 0 | 0 | 0 | 1 | 0 | 2 | 0 | 10 | 5 | 12 | 15 |
24 | ccRCC | T1N0M0 | 1 | no | ND | ND | ND | 0 | 0 | 5 | 0 | 1 | 0 | 0 | 0 | 0 |
25 | ccRCC | T1aN0M0 | 2 | no | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 20 | ND | ND | ND |
28 | ccRCC | T1bN0M0 | 1 | no | 0 | 0 | 0 | 0 | 645 | 0 | 5 | 5 | 25 | 0 | 36 | 12 |
30 | ccRCC | T1N0M0 | 3 | no | 0 | 0 | 0 | 31 | 227 | 4 | 0 | 0 | 0 | 0 | 67 | 64 |
32 | ccRCC | T1aN0M0 | 2 | no | 1 | 0 | 0 | 1 | 0 | 0 | 3 | 26 | 15 | ND | ND | ND |
34 | ccRCC | T1aN0M0 | 2 | no | 0 | 0 | 0 | 0 | 26 | 51 | 0 | 18 | 0 | ND | ND | ND |
35 | ccRCC | T1aN0M0 | 2 | no | 0 | 0 | 0 | 0 | 0 | 0 | ND | ND | ND | 0 | 20 | 0 |
36 | ccRCC | T1aN0M0 | 3 | no | 2 | 125 | 3 | 0 | 0 | 0 | 2 | 1 | 7 | 0 | 0 | 0 |
40 | ccRCC | T1aN0M0 | 3 | no | 0 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 15 | 0 | 0 | 0 |
41 | ccRCC | T1aN0M0 | 3 | no | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 74 | 4 |
42 | ccRCC | T1N0M0 | 1 | no | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 22 | 44 | 58 | 124 | 98 |
27 | pap.RCC | T1bN0M0 | 3 | no | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6 | 0 |
8 | pap.RCC | T1N0M0 | 2 | no | ND | ND | ND | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
12 | pap.RCC | T3aN0M0 | 3 | yes | 0 | 0 | 5 | 0 | 0 | 0 | 11 | 0 | 0 | ND | ND | ND |
31 | pap.RCC | T1aN0M0 | 2 | no | 0 | 0 | 0 | 0 | 0 | 0 | ND | ND | ND | ND | ND | ND |
37 | pap.RCC | T2aN0M0 | 2 | no | 0 | 0 | 100 | 19 | 79 | 18 | 1 | 0 | 4 | ND | ND | ND |
39 | reg RCC | T2aN0M0 | 2 | yes | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
C1 | Control | - | - | - | 0 | 0 | 1 | - | - | - | - | - | - | - | - | - |
C2 | Control | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - |
C3 | Control | - | - | - | 0 | 2 | 2 | - | - | - | - | - | - | - | - | - |
C4 | Control | - | - | - | 0 | 83 | 100 | - | - | - | - | - | - | - | - | - |
C5 | Control | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - |
C6 | Control | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - |
C7 | Control | - | - | - | 0 | 0 | 12 | - | - | - | - | - | - | - | - | - |
C8 | Control | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - |
C9 | Control | - | - | - | 0 | 1 | 0 | - | - | - | - | - | - | - | - | - |
C10 | Control | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - |
C11 | Control | - | - | - | 0 | 1 | 1 | - | - | - | - | - | - | - | - | - |
C12 | Control | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - |
C13 | Control | - | - | - | 0 | 1 | 2 | - | - | - | - | - | - | - | - | - |
C14 | Control | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - |
C15 | Control | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - |
C16 | Control | - | - | - | 0 | 27 | 5 | - | - | - | - | - | - | - | - | - |
C17 | Control | - | - | - | 0 | 1 | 7 | - | - | - | - | - | - | - | - | - |
C18 | Control | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - |
C19 | Control | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - |
C20 | Control | - | - | - | 0 | 1 | 0 | - | - | - | - | - | - | - | - | - |