TY - JOUR AU - Loeser, R. F. AU - Goldring, S. R. AU - Scanzello, C. R. AU - Goldring, M. B. PY - 2012 DA - 2012// TI - Osteoarthritis: a disease of the joint as an organ JO - Arthritis Rheum VL - 64 UR - https://doi.org/10.1002/art.34453 DO - 10.1002/art.34453 ID - Loeser2012 ER - TY - JOUR AU - Lories, R. J. AU - Luyten, F. P. PY - 2011 DA - 2011// TI - The bone-cartilage unit in osteoarthritis JO - Nat Rev Rheumatol VL - 7 UR - https://doi.org/10.1038/nrrheum.2010.197 DO - 10.1038/nrrheum.2010.197 ID - Lories2011 ER - TY - JOUR AU - Lotz, M. PY - 2012 DA - 2012// TI - Osteoarthritis year 2011 in review: biology JO - Osteoarthritis Cartilage VL - 20 UR - https://doi.org/10.1016/j.joca.2011.11.015 DO - 10.1016/j.joca.2011.11.015 ID - Lotz2012 ER - TY - JOUR AU - Poole, A. R. PY - 2012 DA - 2012// TI - Osteoarthritis as a whole joint disease JO - HSS J VL - 8 UR - https://doi.org/10.1007/s11420-011-9248-6 DO - 10.1007/s11420-011-9248-6 ID - Poole2012 ER - TY - JOUR AU - van den Berg, W. B. PY - 2006 DA - 2006// TI - Osteoarthritis year 2010 in review: pathomechanisms JO - Osteoarthritis Cartilage VL - 19 UR - https://doi.org/10.1016/j.joca.2011.01.022 DO - 10.1016/j.joca.2011.01.022 ID - van den Berg2006 ER - TY - JOUR AU - Guilak, F. PY - 2011 DA - 2011// TI - Biomechanical factors in osteoarthritis JO - Best Pract Res Clin Rheumatol VL - 25 UR - https://doi.org/10.1016/j.berh.2011.11.013 DO - 10.1016/j.berh.2011.11.013 ID - Guilak2011 ER - TY - JOUR AU - Kraus, V. B. AU - Burnett, B. AU - Coindreau, J. AU - Cottrell, S. AU - Eyre, D. AU - Gendreau, M. AU - Gardiner, J. AU - Garnero, P. AU - Hardin, J. AU - Henrotin, Y. AU - Heinegard, D. AU - Ko, A. AU - Lohmander, L. S. AU - Matthews, G. AU - Menetski, J. AU - Moskowitz, R. AU - Persiani, S. AU - Poole, A. R. AU - Rousseau, J. C. AU - Todman, M. PY - 2011 DA - 2011// TI - Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis JO - Osteoarthritis Cartilage VL - 19 UR - https://doi.org/10.1016/j.joca.2010.08.019 DO - 10.1016/j.joca.2010.08.019 ID - Kraus2011 ER - TY - JOUR AU - Sandell, L. J. PY - 2012 DA - 2012// TI - Etiology of osteoarthritis: genetics and synovial joint development JO - Nat Rev Rheumatol VL - 8 UR - https://doi.org/10.2174/157339712802083795 DO - 10.2174/157339712802083795 ID - Sandell2012 ER - TY - JOUR AU - Goldring, M. B. AU - Otero, M. PY - 2011 DA - 2011// TI - Inflammation in osteoarthritis JO - Curr Opin Rheumatol VL - 23 UR - https://doi.org/10.1097/BOR.0b013e328349c2b1 DO - 10.1097/BOR.0b013e328349c2b1 ID - Goldring2011 ER - TY - JOUR AU - Kapoor, M. AU - Martel-Pelletier, J. AU - Lajeunesse, D. AU - Pelletier, J. P. AU - Fahmi, H. PY - 2011 DA - 2011// TI - Role of proinflammatory cytokines in the pathophysiology of osteoarthritis JO - Nat Rev Rheumatol VL - 7 UR - https://doi.org/10.1038/nrrheum.2010.196 DO - 10.1038/nrrheum.2010.196 ID - Kapoor2011 ER - TY - JOUR AU - Chen, L. X. AU - Lin, L. AU - Wang, H. J. AU - Wei, X. L. AU - Fu, X. AU - Zhang, J. Y. AU - Yu, C. L. PY - 2008 DA - 2008// TI - Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA JO - Osteoarthritis Cartilage VL - 16 UR - https://doi.org/10.1016/j.joca.2007.06.006 DO - 10.1016/j.joca.2007.06.006 ID - Chen2008 ER - TY - JOUR AU - Chu, X. AU - You, H. AU - Yuan, X. AU - Zhao, W. AU - Li, W. AU - Guo, X. PY - 2013 DA - 2013// TI - Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis JO - Int J Mol Med VL - 31 ID - Chu2013 ER - TY - JOUR AU - Fernandes, J. AU - Tardif, G. AU - Martel-Pelletier, J. AU - Lascau-Coman, V. AU - Dupuis, M. AU - Moldovan, F. AU - Sheppard, M. AU - Krishnan, B. R. AU - Pelletier, J. P. PY - 1999 DA - 1999// TI - In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression JO - Am J Pathol VL - 154 UR - https://doi.org/10.1016/S0002-9440(10)65368-0 DO - 10.1016/S0002-9440(10)65368-0 ID - Fernandes1999 ER - TY - JOUR AU - Frisbie, D. D. AU - Ghivizzani, S. C. AU - Robbins, P. D. AU - Evans, C. H. AU - McIlwraith, C. W. PY - 2002 DA - 2002// TI - Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene JO - Gene Ther VL - 9 UR - https://doi.org/10.1038/sj.gt.3301608 DO - 10.1038/sj.gt.3301608 ID - Frisbie2002 ER - TY - JOUR AU - Ghivizzani, S. C. AU - Lechman, E. R. AU - Kang, R. AU - Tio, C. AU - Kolls, J. AU - Evans, C. H. AU - Robbins, P. D. PY - 1998 DA - 1998// TI - Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects JO - Proc Natl Acad Sci U S A VL - 95 UR - https://doi.org/10.1073/pnas.95.8.4613 DO - 10.1073/pnas.95.8.4613 ID - Ghivizzani1998 ER - TY - JOUR AU - Hsieh, J. L. AU - Shen, P. C. AU - Shiau, A. L. AU - Jou, I. M. AU - Lee, C. H. AU - Teo, M. L. AU - Wang, C. R. AU - Chao, J. AU - Chao, L. AU - Wu, C. L. PY - 2009 DA - 2009// TI - Adenovirus-mediated kallistatin gene transfer ameliorates disease progression in a rat model of osteoarthritis induced by anterior cruciate ligament transection JO - Hum Gene Ther VL - 20 UR - https://doi.org/10.1089/hum.2008.096 DO - 10.1089/hum.2008.096 ID - Hsieh2009 ER - TY - JOUR AU - Hsieh, J. L. AU - Shen, P. C. AU - Shiau, A. L. AU - Jou, I. M. AU - Lee, C. H. AU - Wang, C. R. AU - Teo, M. L. AU - Wu, C. L. PY - 2010 DA - 2010// TI - Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis JO - J Orthop Res VL - 28 UR - https://doi.org/10.1002/jor.21134 DO - 10.1002/jor.21134 ID - Hsieh2010 ER - TY - JOUR AU - Nixon, A. J. AU - Goodrich, L. R. AU - Scimeca, M. S. AU - Witte, T. H. AU - Schnabel, L. V. AU - Watts, A. E. AU - Robbins, P. D. PY - 2007 DA - 2007// TI - Gene therapy in musculoskeletal repair JO - Ann N Y Acad Sci VL - 1117 UR - https://doi.org/10.1196/annals.1402.065 DO - 10.1196/annals.1402.065 ID - Nixon2007 ER - TY - JOUR AU - Oh, H. AU - Chun, C. H. AU - Chun, J. S. PY - 2012 DA - 2012// TI - Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice JO - Arthritis Rheum VL - 64 UR - https://doi.org/10.1002/art.34481 DO - 10.1002/art.34481 ID - Oh2012 ER - TY - JOUR AU - Santangelo, K. S. AU - Nuovo, G. J. AU - Bertone, A. L. PY - 2012 DA - 2012// TI - In vivo reduction or blockade of interleukin-1beta in primary osteoarthritis influences expression of mediators implicated in pathogenesis JO - Osteoarthritis Cartilage VL - 20 UR - https://doi.org/10.1016/j.joca.2012.08.011 DO - 10.1016/j.joca.2012.08.011 ID - Santangelo2012 ER - TY - JOUR AU - Shen, P. C. AU - Shiau, A. L. AU - Jou, I. M. AU - Lee, C. H. AU - Tai, M. H. AU - Juan, H. Y. AU - Lin, P. R. AU - Liu, G. S. AU - Wu, C. L. AU - Hsieh, H. L. PY - 2011 DA - 2011// TI - Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis JO - Exp Biol Med VL - 236 UR - https://doi.org/10.1258/ebm.2010.010319 DO - 10.1258/ebm.2010.010319 ID - Shen2011 ER - TY - JOUR AU - Ruan, M. Z. AU - Erez, A. AU - Guse, K. AU - Dawson, B. AU - Bertin, T. AU - Chen, Y. AU - Jiang, M. M. AU - Yustein, J. AU - Gannon, F. AU - Lee, B. H. PY - 2013 DA - 2013// TI - Proteoglycan 4 expression protects against the development of osteoarthritis JO - Sci Transl Med VL - 5 UR - https://doi.org/10.1126/scitranslmed.3005409 DO - 10.1126/scitranslmed.3005409 ID - Ruan2013 ER - TY - JOUR AU - Smith, P. AU - Shuler, F. D. AU - Georgescu, H. I. AU - Ghivizzani, S. C. AU - Johnstone, B. AU - Niyibizi, C. AU - Robbins, P. D. AU - Evans, C. H. PY - 2000 DA - 2000// TI - Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1 JO - Arthritis Rheum VL - 43 UR - https://doi.org/3.0.CO;2-M DO - 3.0.CO;2-M ID - Smith2000 ER - TY - JOUR AU - Weimer, A. AU - Madry, H. AU - Venkatesan, J. K. AU - Schmitt, G. AU - Frisch, J. AU - Wezel, A. AU - Jung, J. AU - Kohn, D. AU - Terwilliger, E. F. AU - Trippel, S. B. AU - Cucchiarini, M. PY - 2012 DA - 2012// TI - Benefits of recombinant adeno-associated virus (rAAV)-mediated insulin-like growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis JO - Mol Med VL - 18 UR - https://doi.org/10.2119/molmed.2011.00371 DO - 10.2119/molmed.2011.00371 ID - Weimer2012 ER - TY - JOUR AU - Chen, B. AU - Qin, J. AU - Wang, H. AU - Magdalou, J. AU - Chen, L. PY - 2010 DA - 2010// TI - Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits JO - Exp Mol Med VL - 42 UR - https://doi.org/10.3858/emm.2010.42.10.067 DO - 10.3858/emm.2010.42.10.067 ID - Chen2010 ER - TY - JOUR AU - Cucchiarini, M. AU - Terwilliger, E. F. AU - Kohn, D. AU - Madry, H. PY - 2009 DA - 2009// TI - Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer JO - J Cell Mol Med VL - 13 UR - https://doi.org/10.1111/j.1582-4934.2008.00474.x DO - 10.1111/j.1582-4934.2008.00474.x ID - Cucchiarini2009 ER - TY - JOUR AU - Matsumoto, T. AU - Cooper, G. M. AU - Gharaibeh, B. AU - Meszaros, L. B. AU - Li, G. AU - Usas, A. AU - Fu, F. H. AU - Huard, J. PY - 2009 DA - 2009// TI - Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1 JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24443 DO - 10.1002/art.24443 ID - Matsumoto2009 ER - TY - JOUR AU - Cucchiarini, M. AU - Thurn, T. AU - Weimer, A. AU - Kohn, D. AU - Terwilliger, E. F. AU - Madry, H. PY - 2007 DA - 2007// TI - Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9 JO - Arthritis Rheum VL - 56 UR - https://doi.org/10.1002/art.22299 DO - 10.1002/art.22299 ID - Cucchiarini2007 ER - TY - JOUR AU - Li, Y. AU - Tew, S. R. AU - Russell, A. M. AU - Gonzalez, K. R. AU - Hardingham, T. E. AU - Hawkins, R. E. PY - 2004 DA - 2004// TI - Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9 JO - Tissue Eng VL - 10 UR - https://doi.org/10.1089/107632704323061933 DO - 10.1089/107632704323061933 ID - Li2004 ER - TY - JOUR AU - O’Keefe, R. J. AU - Puzas, J. E. AU - Brand, J. S. AU - Rosier, R. N. PY - 1988 DA - 1988// TI - Effect of transforming growth factor-beta on DNA synthesis by growth plate chondrocytes: modulation by factors present in serum JO - Calcif Tissue Int VL - 43 UR - https://doi.org/10.1007/BF02553278 DO - 10.1007/BF02553278 ID - O’Keefe1988 ER - TY - JOUR AU - Redini, F. AU - Galera, P. AU - Mauviel, A. AU - Loyau, G. AU - Pujol, J. P. PY - 1988 DA - 1988// TI - Transforming growth factor beta stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes JO - FEBS Lett VL - 234 UR - https://doi.org/10.1016/0014-5793(88)81327-9 DO - 10.1016/0014-5793(88)81327-9 ID - Redini1988 ER - TY - JOUR AU - Malemud, C. J. PY - 1993 DA - 1993// TI - The role of growth factors in cartilage metabolism JO - Rheum Dis Clin North Am VL - 19 ID - Malemud1993 ER - TY - JOUR AU - Van Beuningen, H. M. AU - van der Kraan, P. M. AU - Arntz, O. J. AU - van den Berg, W. B. PY - 1993 DA - 1993// TI - Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo JO - Ann Rheum Dis VL - 52 UR - https://doi.org/10.1136/ard.52.3.185 DO - 10.1136/ard.52.3.185 ID - Van Beuningen1993 ER - TY - JOUR AU - Ulrich-Vinther, M. AU - Stengaard, C. AU - Schwarz, E. M. AU - Goldring, M. B. AU - Soballe, K. PY - 2005 DA - 2005// TI - Adeno-associated vector mediated gene transfer of transforming growth factor-beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism JO - Eur Cell Mater VL - 10 ID - Ulrich-Vinther2005 ER - TY - JOUR AU - Arai, Y. AU - Kubo, T. AU - Kobayashi, K. AU - Takeshita, K. AU - Takahashi, K. AU - Ikeda, T. AU - Imanishi, J. AU - Takigawa, M. AU - Hirasawa, Y. PY - 1997 DA - 1997// TI - Adenovirus vector-mediated gene transduction to chondrocytes: in vitro evaluation of therapeutic efficacy of transforming growth factor-beta 1 and heat shock protein 70 gene transduction JO - J Rheumatol VL - 24 ID - Arai1997 ER - TY - JOUR AU - Shuler, F. D. AU - Georgescu, H. I. AU - Niyibizi, C. AU - Studer, R. K. AU - Mi, Z. AU - Johnstone, B. AU - Robbins, P. D. AU - Evans, C. H. PY - 2000 DA - 2000// TI - Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes JO - J Orthop Res VL - 18 UR - https://doi.org/10.1002/jor.1100180411 DO - 10.1002/jor.1100180411 ID - Shuler2000 ER - TY - JOUR AU - Arai, Y. AU - Kubo, T. AU - Fushiki, S. AU - Mazda, O. AU - Nakai, H. AU - Iwaki, Y. AU - Imanishi, J. AU - Hirasawa, Y. PY - 2000 DA - 2000// TI - Gene delivery to human chondrocytes by an adeno-associated virus vector JO - J Rheumatol VL - 27 ID - Arai2000 ER - TY - JOUR AU - Madry, H. AU - Cucchiarini, M. AU - Terwilliger, E. F. AU - Trippel, S. B. PY - 2003 DA - 2003// TI - Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage JO - Hum Gene Ther VL - 14 UR - https://doi.org/10.1089/104303403321208998 DO - 10.1089/104303403321208998 ID - Madry2003 ER - TY - JOUR AU - Shi, S. AU - Mercer, S. AU - Eckert, G. J. AU - Trippel, S. B. PY - 2012 DA - 2012// TI - Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transfer JO - J Orthop Res VL - 30 UR - https://doi.org/10.1002/jor.22036 DO - 10.1002/jor.22036 ID - Shi2012 ER - TY - JOUR AU - Lee, D. K. AU - Choi, K. B. AU - Oh, I. S. AU - Song, S. U. AU - Hwang, S. AU - Lim, C. L. AU - Hyun, J. P. AU - Lee, H. Y. AU - Chi, G. F. AU - Yi, Y. AU - Yip, V. AU - Kim, J. AU - Lee, E. B. AU - Noh, M. J. AU - Lee, K. H. PY - 2005 DA - 2005// TI - Continuous transforming growth factor beta1 secretion by cell-mediated gene therapy maintains chondrocyte redifferentiation JO - Tissue Eng VL - 11 UR - https://doi.org/10.1089/ten.2005.11.310 DO - 10.1089/ten.2005.11.310 ID - Lee2005 ER - TY - JOUR AU - Song, S. U. AU - Cha, Y. D. AU - Han, J. U. AU - Oh, I. S. AU - Choi, K. B. AU - Yi, Y. AU - Hyun, J. P. AU - Lee, H. Y. AU - Chi, G. F. AU - Lim, C. L. AU - Ganjei, J. K. AU - Noh, M. J. AU - Kim, S. J. AU - Lee, D. K. AU - Lee, K. H. PY - 2005 DA - 2005// TI - Hyaline cartilage regeneration using mixed human chondrocytes and transforming growth factor-beta1-producing chondrocytes JO - Tissue Eng VL - 11 UR - https://doi.org/10.1089/ten.2005.11.1516 DO - 10.1089/ten.2005.11.1516 ID - Song2005 ER - TY - JOUR AU - Mankin, H. J. AU - Dorfman, H. AU - Lippiello, L. AU - Zarins, A. PY - 1971 DA - 1971// TI - Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data JO - J Bone Joint Surg Am VL - 53 ID - Mankin1971 ER - TY - JOUR AU - Samulski, R. J. AU - Chang, L. S. AU - Shenk, T. PY - 1987 DA - 1987// TI - A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication JO - J Virol VL - 61 ID - Samulski1987 ER - TY - JOUR AU - Samulski, R. J. AU - Chang, L. S. AU - Shenk, T. PY - 1989 DA - 1989// TI - Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression JO - J Virol VL - 63 ID - Samulski1989 ER - TY - JOUR AU - Xiao, X. AU - Li, J. AU - Samulski, R. J. PY - 1998 DA - 1998// TI - Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus JO - J Virol VL - 72 ID - Xiao1998 ER - TY - JOUR AU - Cucchiarini, M. AU - Ekici, M. AU - Schetting, S. AU - Kohn, D. AU - Madry, H. PY - 2011 DA - 2011// TI - Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2 JO - Tissue Eng Part A VL - 17 UR - https://doi.org/10.1089/ten.tea.2011.0018 DO - 10.1089/ten.tea.2011.0018 ID - Cucchiarini2011 ER - TY - JOUR AU - Venkatesan, J. K. AU - Ekici, M. AU - Madry, H. AU - Schmitt, G. AU - Kohn, D. AU - Cucchiarini, M. PY - 2012 DA - 2012// TI - SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells JO - Stem Cell Res Ther VL - 3 UR - https://doi.org/10.1186/scrt113 DO - 10.1186/scrt113 ID - Venkatesan2012 ER - TY - JOUR AU - Shi, S. AU - Mercer, S. AU - Eckert, G. J. AU - Trippel, S. B. PY - 2013 DA - 2013// TI - Growth factor regulation of growth factor production by multiple gene transfer to chondrocytes JO - Growth Factors VL - 31 UR - https://doi.org/10.3109/08977194.2012.750652 DO - 10.3109/08977194.2012.750652 ID - Shi2013 ER - TY - JOUR AU - Dong, Y. AU - Drissi, H. AU - Chen, M. AU - Chen, D. AU - Zuscik, M. J. AU - Schwarz, E. M. AU - O’Keefe, R. J. PY - 2005 DA - 2005// TI - Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta JO - J Cell Biochem VL - 95 UR - https://doi.org/10.1002/jcb.20466 DO - 10.1002/jcb.20466 ID - Dong2005 ER - TY - JOUR AU - Tchetina, E. V. AU - Antoniou, J. AU - Tanzer, M. AU - Zukor, D. J. AU - Poole, A. R. PY - 2006 DA - 2006// TI - Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production JO - Am J Pathol VL - 168 UR - https://doi.org/10.2353/ajpath.2006.050369 DO - 10.2353/ajpath.2006.050369 ID - Tchetina2006 ER - TY - JOUR AU - Gunther, M. AU - Haubeck, H. D. AU - van de Leur, E. AU - Blaser, J. AU - Bender, S. AU - Gutgemann, I. AU - Fischer, D. C. AU - Tschesche, H. AU - Greiling, H. AU - Heinrich, P. C. AU - Graeve, L. PY - 1994 DA - 1994// TI - Transforming growth factor beta 1 regulates tissue inhibitor of metalloproteinases-1 expression in differentiated human articular chondrocytes JO - Arthritis Rheum VL - 37 UR - https://doi.org/10.1002/art.1780370314 DO - 10.1002/art.1780370314 ID - Gunther1994 ER - TY - JOUR AU - Su, S. AU - Grover, J. AU - Roughley, P. J. AU - DiBattista, J. A. AU - Martel-Pelletier, J. AU - Pelletier, J. P. AU - Zafarullah, M. PY - 1999 DA - 1999// TI - Expression of the tissue inhibitor of metalloproteinases (TIMP) gene family in normal and osteoarthritic joints JO - Rheumatol Int VL - 18 UR - https://doi.org/10.1007/s002960050083 DO - 10.1007/s002960050083 ID - Su1999 ER - TY - JOUR AU - Shlopov, B. V. AU - Gumanovskaya, M. L. AU - Hasty, K. A. PY - 2000 DA - 2000// TI - Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis JO - Arthritis Rheum VL - 43 UR - https://doi.org/3.0.CO;2-G DO - 3.0.CO;2-G ID - Shlopov2000 ER - TY - JOUR AU - Blaney Davidson, E. N. AU - Remst, D. F. AU - Vitters, E. L. AU - Van Beuningen, H. M. AU - Blom, A. B. AU - Goumans, M. J. AU - van den Berg, W. B. AU - van der Kraan, P. PY - 2009 DA - 2009// TI - Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice JO - J Immunol VL - 182 UR - https://doi.org/10.4049/jimmunol.0803991 DO - 10.4049/jimmunol.0803991 ID - Blaney Davidson2009 ER - TY - JOUR AU - Finnson, K. W. AU - Parker, W. L. AU - Ten Dijke, P. AU - Thorikay, M. AU - Philip, A. PY - 2008 DA - 2008// TI - ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes JO - J Bone Miner Res VL - 23 UR - https://doi.org/10.1359/jbmr.080209 DO - 10.1359/jbmr.080209 ID - Finnson2008 ER - TY - JOUR AU - van der Kraan, P. M. AU - Goumans, M. J. AU - Blaney Davidson, E. AU - Ten Dijke, P. PY - 2012 DA - 2012// TI - Age-dependent alteration of TGF-beta signalling in osteoarthritis JO - Cell Tissue Res VL - 347 UR - https://doi.org/10.1007/s00441-011-1194-6 DO - 10.1007/s00441-011-1194-6 ID - van der Kraan2012 ER - TY - JOUR AU - Bakker, A. C. AU - van de Loo, F. A. AU - Van Beuningen, H. M. AU - Sime, P. AU - Van Lent, P. L. AU - van der Kraan, P. M. AU - Richards, C. D. AU - van den Berg, W. B. PY - 2001 DA - 2001// TI - Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation JO - Osteoarthritis Cartilage VL - 9 UR - https://doi.org/10.1053/joca.2000.0368 DO - 10.1053/joca.2000.0368 ID - Bakker2001 ER - TY - JOUR AU - Blaney Davidson, E. N. AU - Vitters, E. L. AU - Van Beuningen, H. M. AU - van de Loo, F. A. AU - van den Berg, W. B. AU - van der Kraan, P. M. PY - 2007 DA - 2007// TI - Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation JO - Arthritis Rheum VL - 56 UR - https://doi.org/10.1002/art.23034 DO - 10.1002/art.23034 ID - Blaney Davidson2007 ER - TY - JOUR AU - Blaney Davidson, E. N. AU - Vitters, E. L. AU - van den Berg, W. B. AU - van der Kraan, P. M. PY - 2006 DA - 2006// TI - TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7 JO - Arthritis Res Ther VL - 8 UR - https://doi.org/10.1186/ar1931 DO - 10.1186/ar1931 ID - Blaney Davidson2006 ER - TY - JOUR AU - Mi, Z. AU - Ghivizzani, S. C. AU - Lechman, E. AU - Glorioso, J. C. AU - Evans, C. H. AU - Robbins, P. D. PY - 2003 DA - 2003// TI - Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees JO - Arthritis Res Ther VL - 5 UR - https://doi.org/10.1186/ar745 DO - 10.1186/ar745 ID - Mi2003 ER - TY - JOUR AU - Remst, D. F. AU - Blaney Davidson, E. N. AU - Vitters, E. L. AU - Blom, A. B. AU - Stoop, R. AU - Snabel, J. M. AU - Bank, R. A. AU - van den Berg, W. B. AU - van der Kraan, P. M. PY - 2013 DA - 2013// TI - Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression JO - Osteoarthritis Cartilage VL - 21 UR - https://doi.org/10.1016/j.joca.2012.10.002 DO - 10.1016/j.joca.2012.10.002 ID - Remst2013 ER - TY - JOUR AU - Van Beuningen, H. M. AU - Glansbeek, H. L. AU - van der Kraan, P. M. AU - van den Berg, W. B. PY - 1998 DA - 1998// TI - Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation JO - Osteoarthritis Cartilage VL - 6 UR - https://doi.org/10.1053/joca.1998.0129 DO - 10.1053/joca.1998.0129 ID - Van Beuningen1998 ER - TY - JOUR AU - Miura, Y. AU - Fitzsimmons, J. S. AU - Commisso, C. N. AU - Gallay, S. H. AU - O’Driscoll, S. W. PY - 1994 DA - 1994// TI - Enhancement of periosteal chondrogenesis in vitro. Dose–response for transforming growth factor-beta 1 (TGF-beta 1) JO - Clin Orthop Relat Res VL - 301 ID - Miura1994 ER - TY - JOUR AU - Nishimura, K. AU - Solchaga, L. A. AU - Caplan, A. I. AU - Yoo, J. U. AU - Goldberg, V. M. AU - Johnstone, B. PY - 1999 DA - 1999// TI - Chondroprogenitor cells of synovial tissue JO - Arthritis Rheum VL - 42 UR - https://doi.org/3.0.CO;2-H DO - 3.0.CO;2-H ID - Nishimura1999 ER - TY - JOUR AU - Zhen, G. AU - Wen, C. AU - Jia, X. AU - Li, Y. AU - Crane, J. L. AU - Mears, S. C. AU - Askin, F. B. AU - Frassica, F. J. AU - Chang, W. AU - Yao, J. AU - Carrino, J. A. AU - Cosgarea, A. AU - Artemov, D. AU - Chen, Q. AU - Zhao, Z. AU - Zhou, X. AU - Riley, L. AU - Sponseller, P. AU - Wan, M. AU - Lu, W. W. AU - Cao, X. PY - 2013 DA - 2013// TI - Inhibition of TGF-beta signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis JO - Nat Med VL - 19 UR - https://doi.org/10.1038/nm.3143 DO - 10.1038/nm.3143 ID - Zhen2013 ER - TY - JOUR AU - Nita, I. AU - Ghivizzani, S. C. AU - Galea-Lauri, J. AU - Bandara, G. AU - Georgescu, H. I. AU - Robbins, P. D. AU - Evans, C. H. PY - 1996 DA - 1996// TI - Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo JO - Arthritis Rheum VL - 39 UR - https://doi.org/10.1002/art.1780390515 DO - 10.1002/art.1780390515 ID - Nita1996 ER - TY - JOUR AU - Noh, M. J. AU - Copeland, R. O. AU - Yi, Y. AU - Choi, K. B. AU - Meschter, C. AU - Hwang, S. AU - Lim, C. L. AU - Yip, V. AU - Hyun, J. P. AU - Lee, H. Y. AU - Lee, K. H. PY - 2010 DA - 2010// TI - Pre-clinical studies of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 (TG-C) JO - Cytotherapy VL - 12 UR - https://doi.org/10.3109/14653240903470639 DO - 10.3109/14653240903470639 ID - Noh2010 ER - TY - JOUR AU - Ha, C. W. AU - Noh, M. J. AU - Choi, K. B. AU - Lee, K. H. PY - 2012 DA - 2012// TI - Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients JO - Cytotherapy VL - 14 UR - https://doi.org/10.3109/14653249.2011.629645 DO - 10.3109/14653249.2011.629645 ID - Ha2012 ER - TY - JOUR AU - Scharstuhl, A. AU - Vitters, E. L. AU - van der Kraan, P. M. AU - van den Berg, W. B. PY - 2003 DA - 2003// TI - Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis JO - Arthritis Rheum VL - 48 UR - https://doi.org/10.1002/art.11328 DO - 10.1002/art.11328 ID - Scharstuhl2003 ER -