Figure 5
A schematic illustration of the correlation in mechanisms among detected parameters. Immune recognition of siRNA is via TLR pathway that mainly includes TLR3 (adaptor TRIF) and TLR7 (adaptor MyD88), as well as non-TLR pathway that involves PKR activation. NF-κB and c-Jun are located in convergent points of different signaling pathways and mediate interferons and inflammatory cytokines production. HMGB1 is released by apoptotic or necrotic cells, recognized by TLR2/4 or RAGE and associated with inflammatory responses.