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Table 1 Bodyweight (BW), heart rate (HR), mean arterial pressure (MAP), ejection fraction (EF) and echocardiographic measurements after Ang II infusion in the mice

From: Upregulation of M3 muscarinic receptor inhibits cardiac hypertrophy induced by angiotensin II

Variable WT-CTRL (n = 6) WT-Ang II (n = 6) TG-CTRL (n = 6) TG-Ang II (n = 6)
BW, g 23.18 ± 1.68 20.93 ± 1.54 23.50 ± 1.15 21.30 ± 1.05
HR, bpm 471.74 ± 37.90 642.26 ± 45.85* 470.07 ± 34.77 539.20 ± 54.83#
MAP, mmHg 91.54 ± 3.94 106.57 ± 5.29* 99.44 ± 4.02 88.71 ± 3.72#
Echocardiography(n = 5)
IVSd, mm 0.96 ± 0.05 1.26 ± 0.07* 0.86 ± 0.05 1.02 ± 0.06#
IVSs, mm 1.38 ± 0.06 1.70 ± 0.04* 1.36 ± 0.07 1.42 ± 0.09#
LVPWd, mm 0.94 ± 0.02 1.16 ± 0.07* 0.94 ± 0.05 0.90 ± 0.04#
LVPWs, mm 1.30 ± 0.07 1.44 ± 0.08 1.24 ± 0.04 1.12 ± 0.08#
LVDd, cm 3.24 ± 0.32 3.24 ± 0.16 3.02 ± 0.20 3.00 ± 0.12
LVDs, cm 2.00 ± 0.05 1.84 ± 0.04 1.68 ± 0.04 1.72 ± 0.06
EF 0.75 ± 0.02 0.80 ± 0.04 0.81 ± 0.02 0.77 ± 0.08
  1. IVSd diastolic intraventricular septum thickness, IVSs systolic intraventricular septum thickness, LVPWd diastolic left ventricular posterior wall thickness, LVPWs systolic left ventricular posterior wall thickness, LVDd diastolic systolic left ventricular diameter, LVDs systolic left ventricular diameter, EF ejection fraction. Values were expressed as means ± SEM (n = 6), *P < 0.05 vs. WT-CTRL group; #P < 0.05 vs. WT-Ang II group. WT-CTRL, vehicle-infused wild type (WT) mice; WT-Ang II, angiotensin II (Ang II)-infused WT mice; TG-CTRL, vehicle-infused transgenic (TG) mice; TG-Ang II, Ang II-infused TG mice.