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Table 5 Summary of the multivariate analysis of prognostic factors in nasopharyngeal carcinoma (Including ETAR and CXCR4)

From: The independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways

Clinical endpoint Prognosticator HR 95% CI P value
OS CXCR4 Expression 2.78 1.78-4.35 <0.001
UICC Stage 1.51 1.15-1.98 0.003
N classification 1.47 1.16-1.88 0.001
Gender 0.48 0.29-0.80 0.004
  Age 1.65 1.07-2.56 0.024
PFS CXCR4 Expression 2.30 1.42-3.72 <0.001
ETAR Expression 2.12 1.03-4.36 0.04
  N classification 1.66 1.31-2.08 <0.001
  Gender 0.38 0.21-0.72 0.003
DMFS CXCR4 expression 2.52 1.42-4.46 0.001
ETAR expression 3.46 1.22-9.84 0.02
  N classification 1.96 1.48-2.59 <0.001
LRRFS UICC stage 1.76 1.22-2.54 0.002
  1. CI confidence interval, DMFS distant metastasis-free survival, HR hazard ratio, LRRFS locoregional relapse-free survival, OS overall survival, PFS progression-free survival.