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Table 4 Summary of the multivariate analysis of prognostic factors in nasopharyngeal carcinoma (Excluding ETAR)

From: The independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways

Clinical endpoint Prognosticator HR 95% CI P value
OS CXCR4 expression 2.78 1.78-4.35 <0.001
UICC stage 1.51 1.15-1.98 0.003
N classification 1.47 1.16-1.88 0.002
Gender 0.48 0.29-0.80 0.004
  Age 1.65 1.07-2.56 0.02
PFS CXCR4 expression 2.67 1.67-4.28 <0.001
N classification 1.64 1.3-2.07 <0.001
  Gender 0.36 0.20-0.69 0.00
DMFS CXCR4 expression 3.35 1.90-5.92 <0.001
N classification 1.88 1.42-2.49 <0.001
  Gender 0.49 0.24-0.98 0.046
LRRFS UICC stage 1.76 1.22-2.54 0.002
  1. CI confidence interval, DMFS distant metastasis-free survival, HR hazard ratio, LRRFS locoregional relapse-free survival, OS overall survival, PFS progression-free survival.