The independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways

Table 4 Summary of the multivariate analysis of prognostic factors in nasopharyngeal carcinoma (Excluding ETAR)

Clinical endpoint	Prognosticator	HR	95% CI	P value
OS	CXCR4 expression	2.78	1.78-4.35	<0.001
	UICC stage	1.51	1.15-1.98	0.003
	N classification	1.47	1.16-1.88	0.002
	Gender	0.48	0.29-0.80	0.004
	Age	1.65	1.07-2.56	0.02
PFS	CXCR4 expression	2.67	1.67-4.28	<0.001
PFS	N classification	1.64	1.3-2.07	<0.001
	Gender	0.36	0.20-0.69	0.00
DMFS	CXCR4 expression	3.35	1.90-5.92	<0.001
DMFS	N classification	1.88	1.42-2.49	<0.001
	Gender	0.49	0.24-0.98	0.046
LRRFS	UICC stage	1.76	1.22-2.54	0.002

CI confidence interval, DMFS distant metastasis-free survival, HR hazard ratio, LRRFS locoregional relapse-free survival, OS overall survival, PFS progression-free survival.

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