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Table 3 Summary of the multivariate analysis of prognostic factors in nasopharyngeal carcinoma (Excluding CXCR4)

From: The independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways

Clinical endpoint Prognosticator HR 95% CI P value
OS ETAR expression 1.93 1.11-3.38 0.02
UICC stage 1.54 1.19-2.01 0.001
N classification 1.42 1.12-1.80 0.003
Gender 0.57 0.34-0.93 0.026
  Age 1.98 1.28-3.07 0.002
PFS ETAR expression 2.58 1.28-5.22 0.008
UICC stage 1.36 1.02-1.84 0.04
N classification 1.42 1.1-1.84 0.007
  Gender 0.47 0.25-0.89 0.02
DMFS ETAR expression 4.62 1.66-12.86 0.003
  N classification 1.92 1.46-2.54 <0.001
LRRFS UICC stage 1.76 1.22-2.54 0.002
  1. CI confidence interval, DMFS distant metastasis-free survival, HR hazard ratio, LRRFS locoregional relapse-free survival, OS overall survival, PFS progression-free survival.