Heterogeneous distribution of BRAF/NRAS mutations among Italian patients with advanced melanoma

Table 3 Mutations in BRAF / NRAS genes

Exon	Mutation	Base change	Amino acid change	Mutated samples	%
BRAF
15	V600E	1799	Val to Glu	347	92.3
15	V600E	T > A	Val to Glu	347	92.3
15	V600K	1798-99 GT > AA	Val to Lys	20	5.3
15	V600D	1799-1800	Val to Asp	6	1.6
15	V600D	TG > AT	Val to Asp	6	1.6
15	V600R	1798-99	Val to Arg	2	0.5
15	V600R	GT > AG	Val to Arg	2	0.5
15	L597R	1790	Leu to Arg	1	0.3
15	L597R	T > G	Leu to Arg	1	0.3
NRAS
3	Q61R	182	Gln to Arg	47	58.8
3	Q61R	A > G	Gln to Arg	47	58.8
3	Q61L	182	Gln to Leu	23	28.7
3	Q61L	A > T	Gln to Leu	23	28.7
3	Q61K	181	Gln to Lys	10	12.5
3	Q61K	C > A	Gln to Lys	10	12.5

Frequencies are related to the total amount of mutated cases in BRAF (N = 376) and NRAS (N = 80) genes.

ISSN: 1479-5876