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Figure 5 | Journal of Translational Medicine

Figure 5

From: Anti-tumour activity of longikaurin A (LK-A), a novel natural diterpenoid, in nasopharyngeal carcinoma

Figure 5

LK-A regulates pro-apoptotic and anti-apoptotic molecules and inhibits PI3K/Akt pathway. (A) Increased expression of the pro-apoptotic protein Bax and the ratio of Bax to Bcl-xL occurred in a dose-dependent manner after treatment of CNE1 and CNE2 cells with LK-A for 24 hrs. *p < 0.05 vs. control group (untreated). (B) The phosphorylation levels of Akt and GSK-3 in CNE1 and CNE2 cells were downregulated after treatment with LK-A for 24 hrs.

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