Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Figure 7 | Journal of Translational Medicine

Figure 7

From: Patient-derived tissue slice grafts accurately depict response of high-risk primary prostate cancer to androgen deprivation therapy

Figure 7

ADT induced mislocalization of E-cadherin in TSGs derived from HRPCa-2. E-cadherin, a well known epithelial marker, was primarily localized on cell membranes in cancer cells of human hormone-naive PCa (A) and control TSGs derived from HRPCa-2 (C), while in human PCa treated with ADT (B) and castrated TSGs (D), it was mislocalized away from the cell membrane ( arrow in C) into the nucleus ( arrow in D). The inserts are enlarged images of the boxed area in each image. Magnification for (A) and (B) is 40X, and for (C) and (D), 20X.

Back to article page