Skip to main content
Figure 5 | Journal of Translational Medicine

Figure 5

From: Tumor grafts derived from patients with head and neck squamous carcinoma authentically maintain the molecular and histologic characteristics of human cancers

Figure 5

Gene expression patterns of patient-derived xenografts and parent tumors were distinct from that of human cancer cells in culture. (A) Analysis of gene expression data from parental tumors and human HNSCC cancer cells in culture revealed 1377 probes that were distinct (P < 0.01, unpaired t-test, fold-change >3 in either direction). (B) Comparison of 3 parental tumors to the paired PDXs revealed 627 probes that were distinct (P < 0.01, paired t-test, fold-change >1.4). (C) Comparison of all parental tumors to all PDXs revealed 936 probes that were distinct (P < 0.01, unpaired t-test, fold-change >10). Specific gene ontogeny groups are listed in Additional files 3, 4. For each heat map, genes are centered on a given reference group to show relative expression differences.

Back to article page