Figure 4

Gene expression patterns of patient-derived xenografts, parent tumors, and human cancer cells in culture were distinct. This similarity tree of samples is based on unsupervised clustering of gene expression in parental tumors, PDX, and cells in culture with all samples (A) or excluding cell lines and tumors that failed to engraft (B) (using expression values for all 54,000 gene transcript probes represented in the dataset). Samples that appear on proximate branches of the tree are more similar to each other in terms of their global expression patterns.