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Table 3 Routine blood tests and biochemistry (expressed as mean ± SD)

From: Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study

Items

Treatment groups

P value

Control (n = 8)☆

DOX (n = 11)

PDOX (n = 12)

Peripheral blood routine

RBC (×1012/L)

8.06 ± 3.50

9.59 ± 0.65

9.52 ± 1.47

> 0.05

HGB (g/L)

139.00 ± 9.82

141.18 ± 9.62

138.83 ±19.52

> 0.05

WBC (×109/L)

3.25 ± 1.50

2.71 ± 1.00*

5.37 ± 3.31*

< 0.05

PLT (×109/L)

385.67 ± 102.72*, §

611.36 ± 176.40

644.33 ± 293.34

* < 0.05 vs DOX § < 0.05 vs PDOX

Liver functions

AST (U/L)

489.01 ± 95.85*

338.42 ± 75.47§

444.64 ± 114.01

* < 0.05 vs DOX § < 0.05 vs PDOX

ALT (U/L)

172.83 ± 52.26

219.56 ± 165.57

216.11 ± 153.50

> 0.05

TBIL (μmol/L)

3.51 ± 0.42

3.40 ± 0.50

3.59 ± 0.67

> 0.05

DBIL (μmol/L)

3.21 ± 0.10

3.17 ± 0.11

3.19 ± 0.16

> 0.05

GGT (U/L)

30.28 ± 10.65 *, §

15.75 ± 6.13

18.43 ± 11.06

* < 0.05 vs DOX § < 0.05 vs PDOX

Renal functions

BUN (mmol/L)

15.83 ± 1.72*, §

11.99 ± 3.33 #

9.29 ± 2.40

* < 0.05 vs DOX § < 0.001 vs PDOX # < 0.05 vs PDOX

Cr (μmol/L)

41.73 ± 3.85*

43.37 ± 4.95§

34.76 ± 7.67

* < 0.05 vs PDOX § < 0.05 vs PDOX

Electrolytes

K+ (mmol/L)

6.56 ± 0.60

6.58 ± 0.36

6.81 ± 0.59

> 0.05

Na+ (mmol/L)

160.82 ± 4.04

158.53 ± 2.21

158.50 ± 2.54

> 0.05

Cl- (mmol/L)

114.88 ± 1.86*

113.23 ± 2.66

112.42 ± 1.58*

< 0.05

Ca2+ (mmol/L)

2.25 ± 0.10*

2.31 ± 0.08§

2.38 ± 0.08

* < 0.05 vs PDOX § < 0.05 vs PDOX

Mg2+ (mmol/L)

1.15 ± 0.09

1.23 ± 0.18

1.15 ± 0.34

> 0.05

  1. ☆ Note: Two nude mice died before the study endpoint, leaving only 8 mice available for blood test of routine and biochemistry parameters. *,§, #: denote statistical significances for comparisons of the same item in different groups, as clearly described in the P value column.
  2. WBC: white blood cell; NEUT: neutrophil; RBC: red blood cell; HGB: hemoglobin; PLT: platelet; LYM: lymphocyte; PLT: platelet count; ALT: alanine transaminase; AST: aspartate aminotransferase; TBIL: total bilirubin; DBIL: direct bilirubin; GGT: γ-glutamyltransferase; Cr: creatinine; BUN: Blood urea nitrogen; CK: creatine kinase; CK-MB: creatine kinase-myoglobin; LDH: lactic dehydrogenase.