Items | Treatment groups | P value | ||
---|---|---|---|---|
Control (n = 8)☆ | DOX (n = 11) | PDOX (n = 12) | ||
Peripheral blood routine | ||||
RBC (×1012/L) | 8.06 ± 3.50 | 9.59 ± 0.65 | 9.52 ± 1.47 | > 0.05 |
HGB (g/L) | 139.00 ± 9.82 | 141.18 ± 9.62 | 138.83 ±19.52 | > 0.05 |
WBC (×109/L) | 3.25 ± 1.50 | 2.71 ± 1.00* | 5.37 ± 3.31* | < 0.05 |
PLT (×109/L) | 385.67 ± 102.72*, § | 611.36 ± 176.40 | 644.33 ± 293.34 | * < 0.05 vs DOX § < 0.05 vs PDOX |
Liver functions | ||||
AST (U/L) | 489.01 ± 95.85* | 338.42 ± 75.47§ | 444.64 ± 114.01 | * < 0.05 vs DOX § < 0.05 vs PDOX |
ALT (U/L) | 172.83 ± 52.26 | 219.56 ± 165.57 | 216.11 ± 153.50 | > 0.05 |
TBIL (μmol/L) | 3.51 ± 0.42 | 3.40 ± 0.50 | 3.59 ± 0.67 | > 0.05 |
DBIL (μmol/L) | 3.21 ± 0.10 | 3.17 ± 0.11 | 3.19 ± 0.16 | > 0.05 |
GGT (U/L) | 30.28 ± 10.65 *, § | 15.75 ± 6.13 | 18.43 ± 11.06 | * < 0.05 vs DOX § < 0.05 vs PDOX |
Renal functions | ||||
BUN (mmol/L) | 15.83 ± 1.72*, § | 11.99 ± 3.33 # | 9.29 ± 2.40 | * < 0.05 vs DOX § < 0.001 vs PDOX # < 0.05 vs PDOX |
Cr (μmol/L) | 41.73 ± 3.85* | 43.37 ± 4.95§ | 34.76 ± 7.67 | * < 0.05 vs PDOX § < 0.05 vs PDOX |
Electrolytes | ||||
K+ (mmol/L) | 6.56 ± 0.60 | 6.58 ± 0.36 | 6.81 ± 0.59 | > 0.05 |
Na+ (mmol/L) | 160.82 ± 4.04 | 158.53 ± 2.21 | 158.50 ± 2.54 | > 0.05 |
Cl- (mmol/L) | 114.88 ± 1.86* | 113.23 ± 2.66 | 112.42 ± 1.58* | < 0.05 |
Ca2+ (mmol/L) | 2.25 ± 0.10* | 2.31 ± 0.08§ | 2.38 ± 0.08 | * < 0.05 vs PDOX § < 0.05 vs PDOX |
Mg2+ (mmol/L) | 1.15 ± 0.09 | 1.23 ± 0.18 | 1.15 ± 0.34 | > 0.05 |