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Figure 3 | Journal of Translational Medicine

Figure 3

From: Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study

Figure 3

The cardio-toxicities of animals in the 3 groups. A: Compared with Control, DOX increased CK levels but without statistical significance, while PDOX significantly decreased CK levels compared with DOX (P < 0.05). B: Compared with Control, DOX increased CK-MB levels without significant difference, but PDOX did not increase CK-MB levels. C: Both DOX and PDOX significantly decreased LDH compared with Control group (P < 0.05 and P < 0.05). D &E: There were no observable histopathological changes in the myocardium of the Control mice. F &G: Multiple spotty degenerative changes were observed in the myocardium of the DOX-treated mice. H &I: There were no observable histopathological changes in the myocardium of the PDOX-treated mice.

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Journal of Translational Medicine

ISSN: 1479-5876

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