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Table 2 Contribution of individual TNF-α and LT-α gene polymorphisms in CF lung disease progression

From: TNF gene polymorphisms in cystic fibrosis patients: contribution to the disease progression

TNF genes FVC p* FEV1 p*
TNF-α-308GALT-α + 252AA 96.9 ± 9.5 (n = 12)   91.5 ± 10.4 (n = 12)  
TNF-α-308GGLT-α + 252AA 78.8 ± 2.6 (n = 94) 0.025 70.3 ± 2.8 (n = 94) 0.015
TNF-α-308GALT-α + 252AG 72.5 ± 4.2 (n = 27) 0.008 66.4 ± 5.5 (n = 27) 0.009
TNF-α-308GGLT-α + 252AG 78.1 ± 3.8 (n = 33) 0.025 72.6 ± 4.6 (n = 32) 0.027
TNF-α-308GGLT-α + 252GG together with
TNF-α-308GALT-α + 252GG
76.1 ± 6.8 (n = 11) 0.029 69.3 ± 8.9 (n = 11) 0.039
  1. Boldface shows the favorable genotype in term of CF lung disease progression.
  2. FVC, forced vital capacity; FEV1, forced expiratory volume in 1 sec.
  3. * comparison with TNF-α-308GALT-α + 252AA genotype.