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Table 3 Multivariate analysis of association between on-treatment neutropenia and OS for non-small cell lung cancer and ovarian cancer

From: Impact of baseline and nadir neutrophil index in non-small cell lung cancer and ovarian cancer patients: Assessment of chemotherapy for resolution of unfavourable neutrophilia

Tumour type

HR for death (95% CI)

P-value

NSCLC

  

  Neutropenia grade 0

1.6 (1.02;2.65)

0.04

  Baseline neutrophils ≥ 4.5

2.0 (1.11;3.44)

0.02

  Stage IV cancer

1.8 (1.18;2.71)

0.006

  Relative chemo intensity < 100%

1.7 (1.11;2.60)

0.01

Ovarian cancer

  

  Neutropenia grade 0

1.7 (1.04;2.93)

0.04

  Residual disease > 1 cm

2.9 (1.73;4.81)

0.0001

  Age at diagnosis

1.02 (1.00;1.05)

0.04

  Ascites present

2.2 (1.11;4.23)

0.02

  CA125 not normalized

3.2 (1.75;6.00)

0.0001

  1. Factors with multivariate significance level <0.05 are shown.
  2. Abbreviations: OS overall survival; NSCLC Non-Small Cell Lung Cancer; Grade 0 neutropenia at nadir ≥ 2.0 × 10^9/L; CA125 Cancer antigen 125.
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Journal of Translational Medicine

ISSN: 1479-5876

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