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Table 3 Multivariate analysis of association between on-treatment neutropenia and OS for non-small cell lung cancer and ovarian cancer

From: Impact of baseline and nadir neutrophil index in non-small cell lung cancer and ovarian cancer patients: Assessment of chemotherapy for resolution of unfavourable neutrophilia

Tumour type HR for death (95% CI) P-value
NSCLC   
  Neutropenia grade 0 1.6 (1.02;2.65) 0.04
  Baseline neutrophils ≥ 4.5 2.0 (1.11;3.44) 0.02
  Stage IV cancer 1.8 (1.18;2.71) 0.006
  Relative chemo intensity < 100% 1.7 (1.11;2.60) 0.01
Ovarian cancer   
  Neutropenia grade 0 1.7 (1.04;2.93) 0.04
  Residual disease > 1 cm 2.9 (1.73;4.81) 0.0001
  Age at diagnosis 1.02 (1.00;1.05) 0.04
  Ascites present 2.2 (1.11;4.23) 0.02
  CA125 not normalized 3.2 (1.75;6.00) 0.0001
  1. Factors with multivariate significance level <0.05 are shown.
  2. Abbreviations: OS overall survival; NSCLC Non-Small Cell Lung Cancer; Grade 0 neutropenia at nadir ≥ 2.0 × 10^9/L; CA125 Cancer antigen 125.
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