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Table 2 Association of HIF-1α, c-Met, CA9 and GLUT1 IHC expression with clinicopathological characteristics in cervical cancer

From: Prognostic assessment of hypoxia and metabolic markers in cervical cancer using automated digital image analysis of immunohistochemistry

  HIF-1α c-Met CA9 GLUT1
N Mean score (95% CI) p value N Mean score (95% CI) p value N Mean score (95% CI) p value N Mean score (95% CI) p value
Diagnostic category   < 0.001    < 0.001    < 0.001    < 0.001
Normal a 313 4.4 (4.0-4.7)   346 0.4 (0.3-0.6)   314 0.0 (0.0-0.0)   357 0.9 (0.7-1.1)  
Low grade CIN b 54 5.1 (4.3-5.9)   62 0.6 (0.2-1.0)   55 0.4 (0.0-0.8)   40 1.8 (0.9-2.7)  
High grade CIN b 104 5.4 (4.9-6.0)   115 0.7 (0.4-0.9)   132 1.9 (1.3-2.5)   121 2.2 (1.8-2.7)  
CIS b 56 5.7 (4.9-6.4)   60 1.7 (1.0-2.4)   69 1.3 (0.6-1.9)   73 2.4 (1.7-3.6)  
Cervical cancer b 151 5.4 (4.9-6.0)   152 4.7 (4.0-5.3)   144 2.1 (1.5-2.8)   162 4.0 (3.3-4.6)  
FIGO stage    < 0.001    0.019    0.149   0.243
I 96 4.6 (4.0-5.2)   98 4.2 (3.4-5.0)   95 1.7 (0.9-2.4)   114 4.3 (3.5-5.1)  
II 50 6.9 (5.9-7.9)   49 5.2 (3.9-6.4)   45 2.9 (1.6-4.1)   43 3.1 (2.1-4.0)  
IV 5 6.0 (2.4-9.5)   5 9.2 (3.7-14.6)   4 4.0 (−5.0-13.0)   5 4.0 (0.4-7.5)  
Tumor differentiation   0.350    0.195    0.298   0.169
Well+Moderate 105 5.6 (4.9-6.2)   107 4.4 (3.7-5.2)   105 2.4 (1.6-3.1)   115 4.1 (3.3-4.8)  
Poor 40 5.0 (3.9-6.1)   40 5.4 (4.0-6.9)   37 1.5 (0.3-2.6)   41 3.1 (1.8-4.3)  
Cell Type    0.010    0.325    0.040   0.001
SCC 119 5.8 (5.2-6.4)   118 4.5 (3.7-5.2)   111 1.6 (1.0-2.3)   130 4.4 (3.7-5.2)  
Other 32 4.1 (2.8-5.4)   33 5.3 (3.7-6.9)   33 3.7 (1.8-5.5)   31 1.9 (0.9-2.8)  
Tumor size    0.210    0.195    0.851   0.947
< 4cm 104 5.2 (4.6-5.8)   106 4.9 (4.1-5.7)   100 2.2 (1.4-2.9)   119 4.0 (3.2-4.8)  
≥ 4cm 47 5.9 (4.9-7.0)   46 4.1 (2.9-5.3)   44 2.0 (0.9-3.1)   43 3.9 (2.8-5.0)  
LVSI    0.725    0.001    0.998   0.801
Negative 73 5.0 (4.2-5.7)   74 3.6 (2.7-4.4)   65 2.0 (1.0-3.0)   84 4.0 (3.1-4.9)  
Positive 62 5.1 (4.3-6.0)   62 5.9 (4.8-7.0)   63 2.0 (1.0-3.0)   63 4.3 (3.2-5.3)  
LN metastasis    < 0.001    0.010    0.820   0.001
Negative 100 4.4 (3.9-5.0)   102 4.0 (3.3-4.8)   95 2.0 (1.2-2.8)   113 4.5 (3.7-5.4)  
Positive 37 6.7 (5.5-7.9)   36 6.3 (4.8-7.9)   35 2.2 (0.8-3.6)   36 2.6 (1.6-3.6)  
  1. Some data of tumor differentiation, LVSI and LN metastasis are not available on retrospective chart review. SCC, squamous cell carcinoma; LVSI, lymphovascular space invasion; a normal sample was constructed with nonadjacent normal epithelium from tumor in same patient, bIHC staining of each marker was evaluated with available tumor cores from 209 CIN, 74 CIS and 179 cancer cores.