Kaplan-Meier plots of disease-free survival (A - D) and overall survival (E – H) for categorized by HIF-1α (A & E), c-Met (B & F), CA9 (C & G) and GLUT1 (D & H). High HIF-1α expression shows worse disease-free survival (A, P = 0.002) and overall survival rate (E, P = 0.047) than low expression (P = 0.047). Patients with high c-Met expression displayed shorter disease-free (P = 0.035) and overall survival (P = 0.005) compared with that of patients with low c-Met expression (B &F). P values for two-sided log-rank statistics are given for each plot. Cut-off value of HIF-1α, c-Met, CA9 and GLUT1 are 8, 8, 2 and 8 of IHC score, respectively.