Local and systemic delivery of UCX® cells prevent global arthritic manifestations in the AIA model. Graphical representations of (A, C) AI variation during the time scoped by the AIA model experiment. Animals were scored at pre-selected times based on the sum of the following grades: 0 = normal paw; 1 = for each inflamed paw; 1 = tail lesion; 1 = joint rigidity or deformity; 1 = wounded paw; 1 = infected paw; 1 = necrotic paw. The sum of the parameters was calculated to a maximum AI of 9. Data is presented as mean ± SEM (n = 8). The evolution of clinical signs was photographically recorded (B, D) and compared to both normal and Sham-treated animals. Photos are representative of 8 animals.