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Table 1 Analysis of the retrieved data based on enrichment for gene ontology, category of molecular function

From: A network model of genomic hormone interactions underlying dementia and its translational validation through serendipitous off-target effect

Gene set name Description of annotation P-value
Amine receptor activity GO:0008227: Combining with a biogenic amine to initiate a change in cell activity. 3.61E-05
Hormone activity GO:0005179: The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. 1.46E-04
Copper ion binding GO:0005507: Interacting selectively with copper (Cu) ions. 3.40E-03
Neuropeptide hormone activity GO:0005184: The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids. 6.55E-03
Serotonin receptor activity GO:0004993: Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity. 1.40E-02