Figure 3
Elements of the seven hormonal signaling pathways form the core connected component of the brain interactome (normal state with all possible interactions). Pathway memberships are indicated by color codings; Green: estrogen signaling pathway; Red: insulin signaling pathway; Light blue: leptin signaling pathway; Dark blue: melatonin signaling pathway; Gray: thyroid signaling pathway; Brown: corticotropin-releasing hormone pathway. Yellow color indicates common membership to two or more pathways and also embeds the elements of the growth hormone signaling pathway.