Figure 5

ELISA analyses of inflammatory cytokines (IL-1β, IL-6, and TNF-α), chemokine (MCP-1), tissue inhibitor of metalloproteinases (TIMP-1 and TIMP-2), and growth factors (IGF-1 and TGF-β1) in aortic tissues 4 weeks after operation. Intravenously administered BM-MSCs reduced IL-1β (A), IL-6 (B), and MCP-1 (D) but did not significantly alter expression of TNF-α (C). BM-MSCs also increased expressions of IGF-1 (E), and TIMP-2 (H) but did not alter expressions of TGF-β1 (F) and TIMP-1 (G). All data are presented as mean ± SEM (n =10-12). *P < 0.05, **P < 0.01, and ***P < 0.001 vs. group CONT, assessed by unpaired t-test. IL, interleukin; TNF, tumor necrosis factor; MCP, monocyte chemotactant protein; TGF-β, transforming growth factor β; IGF-1, insulin-like growth factor; TIMP, tissue inhibitor of metalloproteinase.