Figure 2

Multiple intravenous administrations of BM-MSCs attenuated aortic elastin degradation in apoE^−/−mice. A) EVG staining shows normal wavy elastic lamina structure in group Sham, and B) disruption of elastic lamina and aneurysm formation in group CONT. C) Administration of BM-MSCs maintained wavy structure of the elastic lamellae. Scale bar = 200 μm. D) Measurement of elastin volume of aortic tissues showed a significant decrease in group CONT compared with group Sham, but preservation in group MSC4. Data are presented as means ± SEM (n =10-12) **P<0.01, ***P<0.001 vs. group CONT, assessed by one-way ANOVA.