Figure 1

Multiple intravenous administrations of BM-MSCs inhibited AngII-induced aortic aneurysm (AA) formation in apoE^−/−mice. A) Schematic diagram of study design. B) Representative macroscopic images of aorta from group Sham, CONT, and MSC4. Arrowheads indicate typical AAs induced by Ang II in apoE^−/− mice. C) Incidence of Ang II-induced AA was significantly decreased in group MSC4 compared with group CONT. There was no AA formation in group Sham. D-F) Aortic outer diameters measured at ascending, phrenic, and infrarenal levels in apoE^−/− mice. Data are presented as means ± SEM (n =10-12) **P<0.01, ***P<0.001 vs. group CONT, assessed by chi-square test (for AA incidence) and one-way ANOVA (for aortic diameter).