Metallothionein 2A inhibits NF-κB pathway activation and predicts clinical outcome segregated with TNM stage in gastric cancer patients following radical resection

Table 1 Logistic regression analysis of clinicopathological features and prognosis in GC

Variates	No. of cases (n = 258)	Survival time (month)		P-value
Sex
Male	186	66.4 ± 4.6
Female	72	54.1 ± 4.8		0.604
Age at diagnosis
<60	173	65.0 ± 4.9
≥60	85	59.2 ± 5.6		0.867
TNM stage
I	34	105.5 ± 7.7	I vs. IV	< 0.001
II	57	74.0 ± 5.9	II vs. IV	< 0.001
III	115	49.1 ± 3.4	III vs. IV	0.010
IV	52	35.8 ± 4.1
Tumor depth
pT1	13	87.2 ± 9.9	pT1 vs. pT4	0.005
pT2	50	89.1 ± 9.1	pT2 vs. pT4	< 0.001
pT3	157	49.1 ± 2.9	pT3 vs. pT4	0.159
pT4	38	40.1 ± 5.3
Lymph node status
pN0	78	89.8 ± 6.2	pN0 vs. pN3	0.001
pN1	115	50.5 ± 3.4	pN1 vs. pN3	0.212
pN2	49	46.6 ± 6.0	pN2 vs. pN3	0.326
pN3	16	47.5 ± 12.6
Distant metastasis
pM0	232	67.5 ± 4.3
pM1	26	27.6 ± 5.8		< 0.001
Degree of differentiation
D1	54	76.0 ± 6.0
D0	204	59.8 ± 4.4		0.011
MT2A expression				< 0.001
low	202	53.9 ± 3.4
high	56	86.9 ± 9.2
IκB-α expression
low	164	61.6 ± 4.9
high	94	64.9 ± 5.1		0.248
p-IκB-α expression
low	126	74.1 ± 5.3
high	132	47.7 ± 3.4		0.005

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