|
Characteristics
|
3 months prior infusion
|
Baseline data
|
6 months post-1stinfusion
|
12 months post 1stinfusion
|
|---|
|
Total number of patients
|
5
|
14
|
14
|
14
|
|
Male
|
4
|
12
|
NA
|
NA
|
|
Body weight (kgr)
|
79.6±11.2
|
79.6±11.2
|
77.1±8.6
|
76.2±9.4
|
|
Age (yrs)
|
NA
|
64.4±7
|
NA
|
NA
|
|
Ex smokers
|
5
|
14
|
NA
|
NA
|
|
Current smokers
|
0
|
0
|
NA
|
NA
|
|
Previous treatment with corticosteroids
|
5
|
5
|
NA
|
NA
|
|
Other treatment (NAC)
|
5
|
5
|
NA
|
NA
|
|
HRCT
|
5 (typical UIP pattern)
|
14 (typical UIP pattern)
|
NA
|
NA
|
|
VATS
|
2 (typical UIP pattern)
|
6 (2 typical and 4 probable UIP pattern)
|
NA
|
NA
|
|
Emphysema (HRCT)
|
2
|
4
|
NA
|
NA
|
|
sPAP (mmHg) (cardiac echo)
|
29.6 ±9
|
29.6 ±9
|
31.5±7
|
32.4±4
|
|
FVC%pred
|
71.8 ±11.5
|
71.2±15.2
|
73.4 ± 18.1
|
74.4 ± 17.5
|
|
DLCO%pred
|
45.82±9.5
|
48.4±11.1
|
48.9 ± 12.8
|
47.3 ± 12.9
|
|
6MWD
|
501±67.9
|
472.1±55.2
|
477.1 ± 50.3
|
476.4 ± 51.9
|
|
mMRC
|
2.0 ± 0.3
|
2.1 ± 0.6
|
1.7 ± 0.6
|
1.7 ± 0.4
|
|
SGRQ
|
NA
|
35.1±6.8
|
27.8 ± 5.6*
|
28.4 ± 5.7*
|
- Values are expressed as mean ± SD unless otherwise indicated.
- Abbreviations: 6MWD 6-minute Walking Distance, ADSCs-SVF Adipose derived stromal cells-stromal vascular fraction, DL
CO
Diffusion lung capacity for carbon monoxide, FVC Forced Vital Capacity, HRCT High resolution computed tomography, IPF Idiopathic pulmonary fibrosis, mMRC Modified medical research council, NA Non applicable, NAC N-Acetylcysteine, SGRQ Saint George’s Research Questionnaire, sPAP Systolic pulmonary artery pressure, UIP Usual Interstitial Pneumonia, VATS Video-Assisted thoracoscopic surgery.
- *p<0.05 was considered as statistically significant.
