Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity

Table 2 Echocardiographic parameter in 7 months-old mice

	WT	WT + HFD	LepR^S1138	LepR^db/db
n	25	12	30	30
heart rate (bpm)	463 ± 6.5	481 ± 6.7	459 ± 10	460 ± 11
WTh (mm)	0.70 ± 0.01	0.75 ± 0.02	0.85 ± 0.02*** #	0.81 ± 0.02**
ESD (mm)	3.2 ± 0.1	3.5 ± 0.1*	3.2 ± 0.1# §§	3.0 ± 0.1* ###
EDD (mm)	4.3 ± 0.1	4.5 ± 0.1	4.6 ± 0.1** §§	4.3 ± 0.03
LVM (mg)	116 ± 4.2	132 ± 5.8	166 ± 7.2*** # §§	137 ± 5.5**
HW (mg)	118 ± 3.3	121 ± 3.6	135 ± 4.6** §§§	108 ± 2.0
FS (%)	26 ± 0.7	22 ± 0.8	31 ± 1.1* ###	31 ± 0.9** ###

*P < 0.05, **P < 0.01 and ***P < 0.001 vs. WT mice; #P < 0.05 and ###P < 0.001 vs. WT mice fed HFD; §§P < 0.01 and §§§P < 0.001 for the difference between LepR^S1138 and LepR^db/db mice. Abbreviations: bpm, beats per minute; HW, calculated heart weight; EDD, end diastolic diameter; ESD, end systolic diameter; FS, fractional shortening; LVM, left ventricular mass; WTh, wall thickness.

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