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Table 2 Echocardiographic parameter in 7 months-old mice

From: Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity

  WT WT + HFD LepRS1138 LepRdb/db
n 25 12 30 30
heart rate (bpm) 463 ± 6.5 481 ± 6.7 459 ± 10 460 ± 11
WTh (mm) 0.70 ± 0.01 0.75 ± 0.02 0.85 ± 0.02*** # 0.81 ± 0.02**
ESD (mm) 3.2 ± 0.1 3.5 ± 0.1* 3.2 ± 0.1# §§ 3.0 ± 0.1* ###
EDD (mm) 4.3 ± 0.1 4.5 ± 0.1 4.6 ± 0.1** §§ 4.3 ± 0.03
LVM (mg) 116 ± 4.2 132 ± 5.8 166 ± 7.2*** # §§ 137 ± 5.5**
HW (mg) 118 ± 3.3 121 ± 3.6 135 ± 4.6** §§§ 108 ± 2.0
FS (%) 26 ± 0.7 22 ± 0.8 31 ± 1.1* ### 31 ± 0.9** ###
  1. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. WT mice; #P < 0.05 and ###P < 0.001 vs. WT mice fed HFD; §§P < 0.01 and §§§P < 0.001 for the difference between LepRS1138 and LepRdb/db mice. Abbreviations: bpm, beats per minute; HW, calculated heart weight; EDD, end diastolic diameter; ESD, end systolic diameter; FS, fractional shortening; LVM, left ventricular mass; WTh, wall thickness.