| WT | WT + HFD | LepRS1138 | LepRdb/db |
---|---|---|---|---|
n | 25 | 12 | 30 | 30 |
body weight (g) | 29 ± 1.0 | 44 ± 1.9*** | 54 ± 1.1*** ### | 55 ± 1.5*** ### |
VAT (mg) | 0.6 ± 0.1 | 1.7 ± 0.3* | 3.3 ± 0.3*** ### | 2.7 ± 0.2*** # |
serum leptin (ng/mL) | 12 ± 1.3 | 60 ± 6.0*** | 67 ± 5.9*** §§§ | 118 ± 6.8*** ### |
heart weight (mg) | 135 ± 3.6 | 147 ± 5.8 | 212 ± 11*** ### §§§ | 151 ± 5.2 |
normalized heart weight (mg/mm TL) | 7.5 ± 0.2 | 8.2 ± 0.3 | 12 ± 0.6*** ### §§§ | 8.9 ± 0.2 |
normalized heart weight (mg/g BW) | 4.8 ± 0.1 | 3.4 ± 0.2*** | 3.9 ± 0.2*** §§§ | 2.8 ± 0.1*** |
CSA (μm2) | 148 ± 4.6 | 161 ± 6.4 | 183 ± 9.9** | 165 ± 6.5 |