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Table 1 Body, visceral fat and heart weights in 7 months-old mice

From: Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity

 

WT

WT + HFD

LepRS1138

LepRdb/db

n

25

12

30

30

body weight (g)

29 ± 1.0

44 ± 1.9***

54 ± 1.1*** ###

55 ± 1.5*** ###

VAT (mg)

0.6 ± 0.1

1.7 ± 0.3*

3.3 ± 0.3*** ###

2.7 ± 0.2*** #

serum leptin (ng/mL)

12 ± 1.3

60 ± 6.0***

67 ± 5.9*** §§§

118 ± 6.8*** ###

heart weight (mg)

135 ± 3.6

147 ± 5.8

212 ± 11*** ### §§§

151 ± 5.2

normalized heart weight (mg/mm TL)

7.5 ± 0.2

8.2 ± 0.3

12 ± 0.6*** ### §§§

8.9 ± 0.2

normalized heart weight (mg/g BW)

4.8 ± 0.1

3.4 ± 0.2***

3.9 ± 0.2*** §§§

2.8 ± 0.1***

CSA (μm2)

148 ± 4.6

161 ± 6.4

183 ± 9.9**

165 ± 6.5

  1. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. WT mice; #P < 0.05 and ###P < 0.001 vs. WT mice fed HFD; §§§P < 0.001 for the difference between LepRS1138 and LepRdb/db mice. Abbreviations: BW, body weight; CSA, cross-sectional area; HFD, high-fat diet; TL, tibia length; VAT, visceral adipose tissue.