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Table 1 Body, visceral fat and heart weights in 7 months-old mice

From: Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity

  WT WT + HFD LepRS1138 LepRdb/db
n 25 12 30 30
body weight (g) 29 ± 1.0 44 ± 1.9*** 54 ± 1.1*** ### 55 ± 1.5*** ###
VAT (mg) 0.6 ± 0.1 1.7 ± 0.3* 3.3 ± 0.3*** ### 2.7 ± 0.2*** #
serum leptin (ng/mL) 12 ± 1.3 60 ± 6.0*** 67 ± 5.9*** §§§ 118 ± 6.8*** ###
heart weight (mg) 135 ± 3.6 147 ± 5.8 212 ± 11*** ### §§§ 151 ± 5.2
normalized heart weight (mg/mm TL) 7.5 ± 0.2 8.2 ± 0.3 12 ± 0.6*** ### §§§ 8.9 ± 0.2
normalized heart weight (mg/g BW) 4.8 ± 0.1 3.4 ± 0.2*** 3.9 ± 0.2*** §§§ 2.8 ± 0.1***
CSA (μm2) 148 ± 4.6 161 ± 6.4 183 ± 9.9** 165 ± 6.5
  1. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. WT mice; #P < 0.05 and ###P < 0.001 vs. WT mice fed HFD; §§§P < 0.001 for the difference between LepRS1138 and LepRdb/db mice. Abbreviations: BW, body weight; CSA, cross-sectional area; HFD, high-fat diet; TL, tibia length; VAT, visceral adipose tissue.