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Table 1 Baseline characteristics ( n = 359 )

From: Somatostatin-based radiotherapy with [90Y-DOTA]-TOC in neuroendocrine tumors: long-term outcome of a phase I dose escalation study

Characteristic

 

Low dose (n = 60)

Intermediate dose (n = 77)

High dose (n = 222)

Gender

Females

27 (45.0%)

30 (50.6%)

98 (44.1%)

 

Males

33 (55.0%)

47 (49.4%)

124 (55.9%)

Age [y]

Median

51.1

55.4

59.0

 

Range

18.1-77.0

21.9-80.5

20.5-81.1

Disease Duration [y]

Median

1.9

1.4

1.9

 

Range

0.1-25.8

0.1-18.6

0.1-27.5

Pretreatment

Surgery

35 (58.3%)

36 (46.8%)

125 (56.3%)

 

Chemotherapy

14 (23.3%)

16 (20.8%)

38 (17.1%)

 

Radiation

21 (35.0%)

31 (40.3%)

72 (32.4%)

Extent

Single Metastasis

3 (5.0%)

11 (14.3%)

28 (12.6%)

 

Liver Metastases

48 (80.0%)

62 (80.5%)

189 (85.1%)

 

Bone Metastases

16 (26.7%)

17 (22.1%)

47 (21.2%)

Creatinine [μmol/L]

Median

63

71

69

 

Range

22-258

26-138

33-369

Tumor Uptake

Score 1

5 (8.3%)

10 (13.0%)

18 (8.1%)

 

Score 2

6 (10.0%)

8 (10.4%)

11 (5.0%)

 

Score 3

49 (81.7%)

59 (76.6%)

193 (87.0%)

Kidney Uptake

Score 0

2 (3.3%)

3 (3.9%)

11 (5.0%)

 

Score 1

4 (6.6%)

8 (10.4%)

20 (0.2%)

 

Score 2

12 (20.0%)

10 (13.0%)

52 (23.4%)

 

Score 3

42 (70.0%)

55 (71.4%)

137 (61.7%)

Histology

Carcinoid

19 (31.7%)

38 (49.4%)

106 (47.7%)

 

PNET

15 (25.0%)

21 (17.3%)

64 (28.8%)

 

Rare NET

17 (28.3%)

9 (11.7%)

26 (11.7%)

 

Unknown Primary

9 (15.0%)

9 (11.7%)

26 (11.7%)

  1. PNET: pancreatic neuroendocrine tumors, NET: neuroendocrine tumors, Rare NET include: medullary thyroid cancers, neuroblastomas, phaeochromocytomas, paragangliomas, small cell lung cancers and Merkel cell cancers.