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Figure 1 | Journal of Translational Medicine

Figure 1

From: Langerhans-type and monocyte-derived human dendritic cells have different susceptibilities to mRNA electroporation with distinct effects on maturation and activation: implications for immunogenicity in dendritic cell-based immunotherapy

Figure 1

The maturation status of moDCs and LCs affects mRNA-electroporation transfection efficiency. Immature (□) and partially-matured (▤) moDCs (A, C) and LCs (B, D) were electroporated with eGFP-encoding mRNA. The transfection efficiency for each experimental group was assessed by flow cytometry at the indicated time points. Pooled data (mean ± SD, n = 6 independent experiments) are shown for moDCs (A) and LCs (B). *P < .05 and **P < .01 for comparisons between immature and mature groups. Representative histograms of eGFP mRNA-electroporated immature moDCs (C) and partially-matured LCs (D) from one of six independent experiments are shown.

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Journal of Translational Medicine

ISSN: 1479-5876

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