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Figure 3 | Journal of Translational Medicine

Figure 3

From: Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC

Figure 3

Representative phenotypic profiles of % CD4+CD25+CD127-FOXP3+Tregs in good pathological responders (Groups I and II), 200,000 events acquired, and poor pathological responders (Groups III and IV), 200,000 events acquired. AbNs of monocytic (CD11b+ CD14+ HLA DR- CD124+ CD33+) MDSCs, in good pathological responders (Groups I and 11) 400,000 events acquired, and AbNs of granulocytic (CD11b+ CD14- CD66b+ CD124+ CD15+) MDSCs in good pathological responders (Groups I and II), 150,000 events acquired. Data shown are for women with LLABCs, (baseline, post-chemotherapy, post-surgery) and healthy donors.

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