Figure 1

(A) Correlation between % of regulatory FOXP3⁺(CD4⁺CD25⁺CD127^-FOX P3⁺) T cells before and after NAC and subsequent histological response in the breast following NAC (n = 16), graded as complete (cPR, 5), very good (VG, 4), partial (3), poor and no pathological response (2 + 1) in the breast following NAC. Values shown are means ± standard deviations. Statistical analysis: Spearman’s correlation coefficient Rho = −0.620, p = 0.04 (2-tailed) (pre-chemotherapy) and Rho = −0.799, p = 0.05 (2-tailed) (post-chemotherapy) (B) Correlation between % of regulatory CTLA-4⁺ (CD4⁺ CD25⁺ CD152⁺) T cells before and after NAC and subsequent histological response in the breast following NAC (n = 16), graded as complete (cPR, 5), very good (VG, 4), partial (3), poor and no pathological response (2 + 1) in the breast following NAC. Values shown are means ± standard deviations. Statistical analysis: Spearman’s correlation coefficient Rho = 0.260, p = 0.78 (NS) (pre-chemotherapy) and Rho = −0.794, p = 0.01 (2-tailed) (post-chemotherapy).