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Table 1 Study inclusion and exclusion criteria

From: A multi-site feasibility study for personalized medicine in canines with Osteosarcoma

Inclusion criteria

Exclusion criteria

Client-owned pet dogs ≥ 1 year of age, any gender and weight.

Anticipated poor owner compliance.

Informed owner consent prior to enrollment screening.

Pregnant or likely to become pregnant.

Suspected diagnosis of primary appendicular OSA (+/− metastasis) via radiographs and physical exam or confirmed diagnosis based cytology or histopathology of the affected limb.

Receiving/have received treatment for cancer including chemotherapy, bisphosphonate therapy, prednisone therapy, radiation therapy or immunotherapy, other than Non-steroidal Anti-inflammatory Drugs (NSAIDS).

Any disease stage.

Previously amputated limb as a result of OSA.

Naïve (i.e. de novo) cases.

Concurrent malignancy that is non-appendicular OSA.

Planned amputation.

Primary cancer originated at an anatomical sites other than appendicular OSA.

 

Other serious systemic disorder incompatible with this study.

 

Acupuncture treatment less than 2 weeks prior to sample collection day (dogs that have commenced acupuncture > 2 weeks prior to Day 0 can be included but they must stay on their acupuncture treatment during the study period).

 

Dogs that are participating in another clinical trial, (subjects are allowed to enroll on a trial after the samples have been collected).

 

Quality Control (QC) failure (histopathological or genomic).