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Table 2 Performance of PSP/reg1A and hsCRP as individual or combined classifiers to distinguish HNF1A- from HNF4A-MODY

From: Effects of hepatocyte nuclear factor-1A and -4A on pancreatic stone protein/regenerating protein and C-reactive protein gene expression: implications for maturity-onset diabetes of the young

Classification rule

Sensitivity

Specificity

ROC: HNF1A if PSP > 9.34 ng/ml

90%

67%

ROC: HNF1A if CRP < 0.36 mg/L

77%

89%

ROC: HNF1A if PSP/CRP > 0.03

84%

89%

LDA: HNF1A if 1.25 - 0.10*PSP < 0

45%

78%

LDA: HNF1A if −0.69 + 0.63*CRP < 0

90%

33%

LDA: HNF1A if 1.17 - 28.25*PSP/CRP < 0

65%

89%

  1. This data excludes the two subjects with extreme hsCRP levels. Classification rule shows the statistical method and the final rule to determine HNF1A-MODY. Sensitivity gives the percentage of correctly identified HNF1A-MODY; specificity shows the percentage of correctly identified HNF4A-MODY.
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Journal of Translational Medicine

ISSN: 1479-5876

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