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Figure 5 | Journal of Translational Medicine

Figure 5

From: Vaccinia virus expressing bone morphogenetic protein-4 in novel glioblastoma orthotopic models facilitates enhanced tumor regression and long-term survival

Figure 5

The GBM CSCs generate an invasive and infiltrative pattern of tumor growth in nude mouse brains reminiscent of glioblastoma in patients. A) Real time imaging of GBM 010627 FLuc CSC line (GBM CSC 0627 FLuc) after being implanted in the brains of immunocompromised mice. The invasive migratory pattern of cells originating from the site of the GBM CSC implantation (day 42) that can be observed as luminescence (blue) eventually spreads throughout the brain (day 55). B) Real time imaging of U87 FLuc cell line after being implanted in the brains of immunocompromised mice. As opposed to the signal pattern from the GBM CSC line, the signal from the U87FLuc cell line (luminescence, blue) remained localized around the site of implantation in the right part of the cerebrum (day 36) and the tumor tended to enlarge only on that side of the brain (day 49). The green color is a false color given to the nose cones for the animals and their fur to generate adequate contrast with the luminescence (blue).

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