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Table 1 Assessment of PC61-mediated Treg inactivation

From: Impact of anti-CD25 monoclonal antibody on dendritic cell-tumor fusion vaccine efficacy in a murine melanoma model

Naive mice
Day Y13 (%) PC61 (%)
7 16.4 0.887
14 15.5 0.332
21 12.7 0.507
28 16.4 8.410
42 14.6 9.340
Tumor bearing mice
3 7.85 1.02
10 7.40 1.60
20 11.8 1.70
  1. (Top) Naïve C3H/HeN mice were injected intraperitoneally with PC61 mAb or Y13 control mAb, respectively. Mice were sacrificed at the indicated time points and splenocytes were analyzed by FACS after staining with anti-CD4, anti-CD25, and anti-FoxP3. The percentage of triple-positive cells is presented. (Bottom) Lung metastases were established in C57BL/6 mice via tail vein injection of D5lacZ cells. 2 days later, animals received intraperitoneal injections of PC61 or Y13 mAbs. Mice were sacrificed at the indicated time points, splenocytes were analyzed by FACS as described above and the percentage of triple-positive cells was determined.