Figure 8

Proteins involved in complement C3 and A2M functions were analyzed using STRING software. The functional partners were predicted by different methods, which were shown in different line colors (Seen the panels within the figure caption). Blue (, co-occurrence), means the presence of linked proteins across species; black (, coexpression), means the genes co-expressed in the same or in other species; purple (, experiments), shows a significant protein interaction from the reports of literatures; light blue (, database), shows a significant protein interaction groups gathered from databases; green (, textmining), shows protein interaction groups extracted from scientific literatures. The predicted functional partners include as follows. CFH, complement factor H; CR2, complement component receptor 2; CFI, complement factor I; VSIG4, V-set and immunoglobulin domain containing 4; C3AR1, complement component 3a receptor 1; CR1, complement component (3b/4b) receptor 1; CD46, CD46 molecule, complement regulatory protein; CFD, complement factor D; C5AR1, complement component 5a receptor 1; CFB, complement factor B; APP, Amyloid beta (A4) precursor protein; KLKB1, plasma kallikrein; TGFB1, transforming growth factor, beta 1; SERPINE1, serpin peptidase inhibitor, clade E, member 1; SERPINF2, serpin peptidase inhibitor; ALB, albumin; CTSB, cathepsin B; SERPINA1, serpin peptidase inhibitor, clade A, member 1; PLG, plasminogen; EGF, epidermal growth factor.