Removal efficiency of serum high-abundant proteins. 40 μl of healthy human plasma was processed with the ProteoExtractTM Albumin Remove reagent. 50 μg protein from each fraction was separated by SDS-PAGE and visualized by silver staining. The aggregation of HAS (A); IgG heavy chain (B) and IgG light chain (C) was greatly reduced. P: human plasma, R: plasma without high-abundant proteins.