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Table 5 Summary of serum Cytokines values at screening, 1 month & 6 month follow-up after BM-MSC implantation

From: A double blind randomized placebo controlled phase I/II study assessing the safety and efficacy of allogeneic bone marrow derived mesenchymal stem cell in critical limb ischemia

Test Screening 1 month 6 months Normal range (pg/ml)
  BM-MSC arm Placebo BM-MSC arm Placebo BM-MSC arm Placebo  
  N = 10 N = 10 N = 9 N = 10 N = 7 N = 10  
  Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD)  
Gamma - Interferon (pg/ml) 24.4(13.35) 23.1(24.07) 37.8 (34.35) 20(24.67) 9.1(6.34) 6.6(3.57) 0.01 - 168
Interleukin - 1 (pg/ml) 22.6(14.73) 22.9(15.31) 33.1(23.59) 22.9(21.73) 26.6(29.28) 10(3.26) 0 - 400
Tumor Necrosis Factor - alpha (pg/ml) 14.2(9.16) 13.8(10.11) 16.6(6.16) 15.7(7.98) 11.4(11.65) 4.4(2.47) 0 – 3.22