Effects of dexmedetomidine on the plasma level of adhesion molecule ICAM-1 and chemokine MCP-1 following renal I/R-induced injury. The concentration of plasma ICAM-1 (A) and MCP-1 (B) were measured at 48 h following renal I/R injury in the sham, IRI, DMSO, Atip, DEX and AG490 groups. Data were represented as mean ± SEM (n = 8). *P < 0.05 and **P < 0.01 vs. the sham group. #P < 0.05 vs. the IRI and DMSO groups. $P < 0.05 vs. the DEX group.